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IL5

GENERAL INFORMATION

Gene name

 IL5

Gene description

 Interleukin 5

Protein class

 Cancer-related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Secret and plasma positivity in a group of tissues, including testis.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
CAB010304
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 IL5 (HGNC Symbol)

Synonyms

 EDF, IL-5, TRF

Description

 Interleukin 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 132541444 - 132556838

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113525 (version 83.38)

Entrez gene

 3567

UniProt

 P05113 (UniProt - Evidence at protein level)

neXtProt

 NX_P05113

Antibodypedia

 IL5 antibodies

PROTEIN BROWSER
IL5-001
IL5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL5-001
ENSP00000231454
ENST00000231454
P05113 [Direct mapping]
Interleukin-5
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Biotech drugs
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GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005125 [cytokine activity]
GO:0005137 [interleukin-5 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030890 [positive regulation of B cell proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045645 [positive regulation of eosinophil differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0071803 [positive regulation of podosome assembly]
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 134 aa
15.2 kDa 		Yes 0
IL5-002
ENSP00000409825
ENST00000450655
C9JQP9 [Direct mapping]
Interleukin-5
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Predicted intracellular proteins
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GO:0005137 [interleukin-5 receptor binding]
GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0008083 [growth factor activity]
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 51 aa
5.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.