Expression of LIFR in cancer - Summary - The Human Protein Atlas

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LIFR

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LIFR
Gene description	Leukemia inhibitory factor receptor alpha
Protein class	Cancer-related genes CD markers Disease related genes Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, SCLC-21H)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB010252
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB010252

GENE INFORMATION
Gene name	LIFR (HGNC Symbol)
Synonyms	CD118
Description	Leukemia inhibitory factor receptor alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	p13.1
Chromosome location (bp)	38474963 - 38608354
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113594 (version 83.38)
Entrez gene	3977
UniProt	P42702 (UniProt - Evidence at protein level)
neXtProt	NX_P42702
Antibodypedia	LIFR antibodies

PROTEIN BROWSER

LIFR-001	LIFR-003	LIFR-004	LIFR-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIFR-001 ENSP00000263409 ENST00000263409	P42702 [Direct mapping] Leukemia inhibitory factor receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0004897 [ciliary neurotrophic factor receptor activity] GO:0004923 [leukemia inhibitory factor receptor activity] GO:0004924 [oncostatin-M receptor activity] GO:0005127 [ciliary neurotrophic factor receptor binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010656 [negative regulation of muscle cell apoptotic process] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019838 [growth factor binding] GO:0019955 [cytokine binding] GO:0031100 [organ regeneration] GO:0034097 [response to cytokine] GO:0038165 [oncostatin-M-mediated signaling pathway] GO:0043235 [receptor complex] GO:0046982 [protein heterodimerization activity] GO:0048812 [neuron projection morphogenesis] GO:0048861 [leukemia inhibitory factor signaling pathway] GO:0070062 [extracellular exosome] GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway] Show all	1097 aa 123.7 kDa	Yes	1
LIFR-003 ENSP00000398368 ENST00000453190	P42702 [Direct mapping] Leukemia inhibitory factor receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0004897 [ciliary neurotrophic factor receptor activity] GO:0004923 [leukemia inhibitory factor receptor activity] GO:0004924 [oncostatin-M receptor activity] GO:0005127 [ciliary neurotrophic factor receptor binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019838 [growth factor binding] GO:0034097 [response to cytokine] GO:0038165 [oncostatin-M-mediated signaling pathway] GO:0043235 [receptor complex] GO:0048861 [leukemia inhibitory factor signaling pathway] GO:0070062 [extracellular exosome] GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway] Show all	1097 aa 123.7 kDa	Yes	1
LIFR-004 ENSP00000426685 ENST00000506990	D6RF33 [Direct mapping] Leukemia inhibitory factor receptor Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	126 aa 14.5 kDa	Yes	0
LIFR-005 ENSP00000427310 ENST00000511561	D6RJ94 [Direct mapping] Leukemia inhibitory factor receptor Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	75 aa 8.8 kDa	Yes	0

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