Fields »
ABOUT
HELP
BLOG
WWC1

GENERAL INFORMATION

Gene name

 WWC1

Gene description

 WW and C2 domain containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RPTEC TERT1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA038016 , HPA038017
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038016
HPA038017

GENE INFORMATION

Gene name

 WWC1 (HGNC Symbol)

Synonyms

 KIAA0869, KIBRA, PPP1R168

Description

 WW and C2 domain containing 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

 5

Cytoband

 q34

Chromosome location (bp)

 168291651 - 168472303

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113645 (version 83.38)

Entrez gene

 23286

UniProt

 Q8IX03 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IX03

Antibodypedia

 WWC1 antibodies

PROTEIN BROWSER
WWC1-001
WWC1-002
WWC1-004
WWC1-006
WWC1-007
WWC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WWC1-001
ENSP00000265293
ENST00000265293
Q8IX03 [Direct mapping]
Protein KIBRA
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0016477 [cell migration]
GO:0019900 [kinase binding]
GO:0030010 [establishment of cell polarity]
GO:0032386 [regulation of intracellular transport]
GO:0032587 [ruffle membrane]
GO:0032947 [protein complex scaffold]
GO:0035329 [hippo signaling]
GO:0035330 [regulation of hippo signaling]
GO:0035331 [negative regulation of hippo signaling]
GO:0043410 [positive regulation of MAPK cascade]
GO:0046621 [negative regulation of organ growth]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 1113 aa
125.3 kDa 		No 0
WWC1-002
ENSP00000427772
ENST00000521089
Q8IX03 [Direct mapping]
Protein KIBRA
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0016477 [cell migration]
GO:0019900 [kinase binding]
GO:0030010 [establishment of cell polarity]
GO:0030674 [protein binding, bridging]
GO:0032386 [regulation of intracellular transport]
GO:0032587 [ruffle membrane]
GO:0032947 [protein complex scaffold]
GO:0035329 [hippo signaling]
GO:0035330 [regulation of hippo signaling]
GO:0035331 [negative regulation of hippo signaling]
GO:0043234 [protein complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0046621 [negative regulation of organ growth]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 1119 aa
125.9 kDa 		No 0
WWC1-004
ENSP00000377473
ENST00000393895
H3BLZ3 [Direct mapping]
Protein KIBRA
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1080 aa
121.1 kDa 		No 0
WWC1-006
ENSP00000429339
ENST00000524228
H0YBE8 [Direct mapping]
Protein KIBRA
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 889 aa
99 kDa 		No 0
WWC1-007
ENSP00000428084
ENST00000524038
H0YAU4 [Direct mapping]
Protein KIBRA
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 444 aa
50.6 kDa 		No 0
WWC1-201
ENSP00000483898
ENST00000619752
A0A087X148 [Direct mapping]
Protein KIBRA
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 337 aa
38.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.