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SMAD5

GENERAL INFORMATION

Gene name

 SMAD5

Gene description

 SMAD family member 5

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membrane expression in several tissues, most abundant in epithelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA058931
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA058931

GENE INFORMATION

Gene name

 SMAD5 (HGNC Symbol)

Synonyms

 Dwfc, JV5-1, MADH5

Description

 SMAD family member 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 136132845 - 136188747

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113658 (version 83.38)

Entrez gene

 4090

UniProt

 Q99717 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99717

Antibodypedia

 SMAD5 antibodies

PROTEIN BROWSER
SMAD5-001
SMAD5-002
SMAD5-003
SMAD5-004
SMAD5-005
SMAD5-008
SMAD5-010
SMAD5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMAD5-001
ENSP00000441954
ENST00000545279
Q99717 [Direct mapping]
Mothers against decapentaplegic homolog 5
Q68DB7 [Target identity:100%; Query identity:100%]
Mothers against decapentaplegic homolog
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Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001503 [ossification]
GO:0001657 [ureteric bud development]
GO:0001880 [Mullerian duct regression]
GO:0002051 [osteoblast fate commitment]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007281 [germ cell development]
GO:0009880 [embryonic pattern specification]
GO:0016021 [integral component of membrane]
GO:0030218 [erythrocyte differentiation]
GO:0030509 [BMP signaling pathway]
GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051216 [cartilage development]
GO:0060048 [cardiac muscle contraction]
GO:0060348 [bone development]
GO:0060395 [SMAD protein signal transduction]
GO:0071141 [SMAD protein complex]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071773 [cellular response to BMP stimulus]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
Show all
 465 aa
52.3 kDa 		No 0
SMAD5-002
ENSP00000425749
ENST00000507118
D6RIZ9 [Direct mapping]
Mothers against decapentaplegic homolog 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
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 128 aa
14.7 kDa 		No 0
SMAD5-003
ENSP00000424279
ENST00000511116
D6RBB4 [Direct mapping]
Mothers against decapentaplegic homolog 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 134 aa
15.4 kDa 		No 0
SMAD5-004
ENSP00000426696
ENST00000509297
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1 aa
0.1 kDa 		No 0
SMAD5-005
ENSP00000427330
ENST00000515005
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1 aa
0.1 kDa 		No 0
SMAD5-008
ENSP00000422954
ENST00000506223
D6R9D4 [Direct mapping]
Mothers against decapentaplegic homolog 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 80 aa
8.8 kDa 		No 0
SMAD5-010
ENSP00000427474
ENST00000507637
H0YAK7 [Direct mapping]
Mothers against decapentaplegic homolog 5
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 174 aa
19.1 kDa 		No 0
SMAD5-201
ENSP00000446474
ENST00000545620
Q99717 [Direct mapping]
Mothers against decapentaplegic homolog 5
Q68DB7 [Target identity:100%; Query identity:100%]
Mothers against decapentaplegic homolog
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0009880 [embryonic pattern specification]
GO:0016021 [integral component of membrane]
GO:0030509 [BMP signaling pathway]
GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0060395 [SMAD protein signal transduction]
GO:0071141 [SMAD protein complex]
GO:0071773 [cellular response to BMP stimulus]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
Show all
 465 aa
52.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.