Cell atlas - BNIP1 - The Human Protein Atlas

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BNIP1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	BNIP1
Gene description	BCL2/adenovirus E1B 19kDa interacting protein 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA008149
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008149	MCF7	Endoplasmic reticulum
	HPA008149	SK-MEL-30	No staining
	HPA008149	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	BNIP1 (HGNC Symbol)
Synonyms	Nip1, SEC20
Description	BCL2/adenovirus E1B 19kDa interacting protein 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]
Chromosome	5
Cytoband	q35.1
Chromosome location (bp)	173144442 - 173164387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113734 (version 83.38)
Entrez gene	662
UniProt	Q12981 (UniProt - Evidence at protein level)
neXtProt	NX_Q12981
Antibodypedia	BNIP1 antibodies

PROTEIN BROWSER

BNIP1-001	BNIP1-002	BNIP1-003	BNIP1-004	BNIP1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BNIP1-001 ENSP00000239215 ENST00000351486	Q12981 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0007029 [endoplasmic reticulum organization] GO:0016192 [vesicle-mediated transport] GO:0016320 [endoplasmic reticulum membrane fusion] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031201 [SNARE complex] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0097194 [execution phase of apoptosis] Show all	228 aa 26.1 kDa	No	1
BNIP1-002 ENSP00000231668 ENST00000231668	Q12981 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0007029 [endoplasmic reticulum organization] GO:0016192 [vesicle-mediated transport] GO:0016320 [endoplasmic reticulum membrane fusion] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031201 [SNARE complex] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0097194 [execution phase of apoptosis] Show all	271 aa 31.1 kDa	No	1
BNIP1-003 ENSP00000377365 ENST00000393770	Q12981 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0007029 [endoplasmic reticulum organization] GO:0016192 [vesicle-mediated transport] GO:0016320 [endoplasmic reticulum membrane fusion] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031201 [SNARE complex] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0097194 [execution phase of apoptosis] Show all	194 aa 22.4 kDa	No	1
BNIP1-004 ENSP00000239214 ENST00000352523	Q12981 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0007029 [endoplasmic reticulum organization] GO:0016192 [vesicle-mediated transport] GO:0016320 [endoplasmic reticulum membrane fusion] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031201 [SNARE complex] GO:0043066 [negative regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0097194 [execution phase of apoptosis] Show all	237 aa 27.3 kDa	No	1
BNIP1-005 ENSP00000429717 ENST00000519459	H0YBK7 [Direct mapping] Vesicle transport protein SEC20 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.