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HRH2

GENERAL INFORMATION

Gene name

 HRH2

Gene description

 Histamine receptor H2

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Cell line enhanced (RPMI-8226, SK-MEL-30, THP-1, U-937)
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a subset of cells in gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. External data suggests that Histamine H2 receptor mediates gastric acid secretion.

Reliability score

 Approved based on 1 antibody.
HPA013770
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013770

GENE INFORMATION

Gene name

 HRH2

Synonyms

Description

 Histamine receptor H2 (HGNC Symbol)

Entrez gene summary

 Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

 5

Cytoband

 q35.2

Chromosome location (bp)

 175658030 - 175686242

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113749 (version 83.38)

Entrez gene

 3274

UniProt

 P25021 (UniProt - Evidence at transcript level)

neXtProt

 NX_P25021

Antibodypedia

 HRH2 antibodies

PROTEIN BROWSER
HRH2-001
HRH2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HRH2-001
ENSP00000366506
ENST00000377291
P25021 [Direct mapping]
Histamine H2 receptor
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0001696 [gastric acid secretion]
GO:0001697 [histamine-induced gastric acid secretion]
GO:0001698 [gastrin-induced gastric acid secretion]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0003382 [epithelial cell morphogenesis]
GO:0004930 [G-protein coupled receptor activity]
GO:0004969 [histamine receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008542 [visual learning]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0045907 [positive regulation of vasoconstriction]
GO:0048167 [regulation of synaptic plasticity]
GO:0048565 [digestive tract development]
GO:0048732 [gland development]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
GO:1901998 [toxin transport]
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 397 aa
44.5 kDa 		No 7
HRH2-002
ENSP00000231683
ENST00000231683
P25021 [Direct mapping]
Histamine H2 receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001697 [histamine-induced gastric acid secretion]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0004930 [G-protein coupled receptor activity]
GO:0004969 [histamine receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007612 [learning]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0045907 [positive regulation of vasoconstriction]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
Show all
 359 aa
40.1 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.