Cell atlas - ZNF346 - The Human Protein Atlas

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ZNF346

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZNF346
Gene description	Zinc finger protein 346
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA018485
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018485	A-431	Nucleoplasm
	HPA018485	U-2 OS	Nucleus
	HPA018485	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	ZNF346 (HGNC Symbol)
Synonyms	JAZ, Zfp346
Description	Zinc finger protein 346 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	177022696 - 177081189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113761 (version 83.38)
Entrez gene	23567
UniProt	Q9UL40 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UL40
Antibodypedia	ZNF346 antibodies

PROTEIN BROWSER

ZNF346-001	ZNF346-002	ZNF346-003	ZNF346-004	ZNF346-005	ZNF346-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF346-001 ENSP00000350869 ENST00000358149	Q9UL40 [Direct mapping] Zinc finger protein 346 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002039 [p53 binding] GO:0003676 [nucleic acid binding] GO:0003725 [double-stranded RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0019899 [enzyme binding] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] Show all	294 aa 32.9 kDa	No	0
ZNF346-002 ENSP00000423515 ENST00000506693	B7Z4J8 [Direct mapping] Zinc finger protein 346; cDNA FLJ52564, moderately similar to Zinc finger protein 346 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	196 aa 21.7 kDa	No	0
ZNF346-003 ENSP00000421089 ENST00000512315	B7Z4N4 [Direct mapping] Zinc finger protein 346; cDNA FLJ60707, moderately similar to Zinc finger protein 346 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	118 aa 12.8 kDa	No	0
ZNF346-004 ENSP00000421212 ENST00000503425	Q9UL40 [Direct mapping] Zinc finger protein 346 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002039 [p53 binding] GO:0003676 [nucleic acid binding] GO:0003725 [double-stranded RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0019899 [enzyme binding] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] Show all	262 aa 29.3 kDa	No	0
ZNF346-005 ENSP00000425725 ENST00000511834	D6RJ07 [Direct mapping] Zinc finger protein 346 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	310 aa 34.6 kDa	No	0
ZNF346-008 ENSP00000424495 ENST00000503039	Q9UL40 [Direct mapping] Zinc finger protein 346 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002039 [p53 binding] GO:0003676 [nucleic acid binding] GO:0003725 [double-stranded RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0019899 [enzyme binding] GO:0043065 [positive regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] Show all	319 aa 35.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.