Cell atlas - UNC5A - The Human Protein Atlas

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UNC5A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	UNC5A
Gene description	Unc-5 netrin receptor A
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Cell line enriched (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071450
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071450	MCF7	No staining
	HPA071450	SH-SY5Y	Cytosol
	HPA071450	U-2 OS	Plasma membrane
	HPA071450	U-2 OS	Cytosol

GENE INFORMATION
Gene name	UNC5A (HGNC Symbol)
Synonyms	KIAA1976, UNC5H1
Description	Unc-5 netrin receptor A (HGNC Symbol)
Entrez gene summary	UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	176810477 - 176880895
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113763 (version 83.38)
Entrez gene	90249
UniProt	Q6ZN44 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZN44
Antibodypedia	UNC5A antibodies

PROTEIN BROWSER

UNC5A-001	UNC5A-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UNC5A-001 ENSP00000332737 ENST00000329542	Q6ZN44 [Direct mapping] Netrin receptor UNC5A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0012501 [programmed cell death] GO:0016021 [integral component of membrane] GO:0031175 [neuron projection development] GO:0031226 [intrinsic component of plasma membrane] GO:0032589 [neuron projection membrane] GO:0032809 [neuronal cell body membrane] GO:0033564 [anterior/posterior axon guidance] GO:0038007 [netrin-activated signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] Show all	842 aa 92.9 kDa	Yes	1
UNC5A-003 ENSP00000421795 ENST00000509580	H0Y8R2 [Direct mapping] Netrin receptor UNC5A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	344 aa 37.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.