Expression of CRBN in cancer - Summary - The Human Protein Atlas

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CRBN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CRBN
Gene description	Cereblon
Protein class	Disease related genes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA045910
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045910

GENE INFORMATION
Gene name	CRBN (HGNC Symbol)
Synonyms	MRT2, MRT2A
Description	Cereblon (HGNC Symbol)
Entrez gene summary	This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Chromosome	3
Cytoband	p26.2
Chromosome location (bp)	3148992 - 3179710
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113851 (version 83.38)
Entrez gene	51185
UniProt	Q96SW2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96SW2
Antibodypedia	CRBN antibodies

PROTEIN BROWSER

CRBN-001	CRBN-004	CRBN-005	CRBN-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRBN-001 ENSP00000231948 ENST00000231948	Q96SW2 [Direct mapping] Protein cereblon A0A024R2H8 [Target identity:100%; Query identity:100%] Cereblon, isoform CRA_c Show all	Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004176 [ATP-dependent peptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0031464 [Cul4A-RING E3 ubiquitin ligase complex] GO:0032463 [negative regulation of protein homooligomerization] GO:0034766 [negative regulation of ion transmembrane transport] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] GO:0090073 [positive regulation of protein homodimerization activity] Show all	442 aa 50.5 kDa	No	0
CRBN-004 ENSP00000412499 ENST00000432408	Q96SW2 [Direct mapping] Protein cereblon Show all	Predicted intracellular proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004176 [ATP-dependent peptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0031464 [Cul4A-RING E3 ubiquitin ligase complex] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] Show all	441 aa 50.5 kDa	No	0
CRBN-005 ENSP00000411047 ENST00000424814	J3QT87 [Direct mapping] Protein cereblon Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004176 [ATP-dependent peptidase activity] GO:0006508 [proteolysis] Show all	394 aa 45.3 kDa	No	0
CRBN-010 ENSP00000392073 ENST00000450014	J3QT51 [Direct mapping] Protein cereblon Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004176 [ATP-dependent peptidase activity] GO:0006508 [proteolysis] Show all	228 aa 26.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.