Expression of CLDN16 in cancer - Summary - The Human Protein Atlas

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CLDN16

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLDN16
Gene description	Claudin 16
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (ovarian cancer, thyroid cancer)
HPA (cell line):	Group enriched (EFO-21, RPTEC TERT1)
HPA (normal tissue):	Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of cells in kidney

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA056020
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (ovarian cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056020

GENE INFORMATION
Gene name	CLDN16 (HGNC Symbol)
Synonyms	HOMG3, PCLN1
Description	Claudin 16 (HGNC Symbol)
Entrez gene summary	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010]
Chromosome	3
Cytoband	q28
Chromosome location (bp)	190322541 - 190412143
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113946 (version 83.38)
Entrez gene	10686
UniProt	Q9Y5I7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5I7
Antibodypedia	CLDN16 antibodies

PROTEIN BROWSER

CLDN16-001	CLDN16-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN16-001 ENSP00000264734 ENST00000264734	Q9Y5I7 [Direct mapping] Claudin-16 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0006811 [ion transport] GO:0006875 [cellular metal ion homeostasis] GO:0007588 [excretion] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0051928 [positive regulation of calcium ion transport] GO:0070633 [transepithelial transport] GO:1903830 [magnesium ion transmembrane transport] Show all	305 aa 33.8 kDa	No	4
CLDN16-002 ENSP00000414136 ENST00000456423	A0SDD8 [Direct mapping] Claudin-16; PCLN-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005198 [structural molecule activity] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	119 aa 13.5 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.