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CD86

GENERAL INFORMATION

Gene name

 CD86

Gene description

 CD86 molecule

Protein class

 CD markers
FDA approved drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (HDLM-2)
HPA (normal tissue):Tissue enhanced (appendix)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues including, lymphoid tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB004319
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB004319

GENE INFORMATION

Gene name

 CD86 (HGNC Symbol)

Synonyms

 B7-2, B7.2, CD28LG2

Description

 CD86 molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

Chromosome

 3

Cytoband

 q13.33

Chromosome location (bp)

 122055366 - 122121139

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114013 (version 83.38)

Entrez gene

 942

UniProt

 P42081 (UniProt - Evidence at protein level)

neXtProt

 NX_P42081

Antibodypedia

 CD86 antibodies

PROTEIN BROWSER
CD86-001
CD86-002
CD86-003
CD86-004
CD86-005
CD86-007
CD86-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD86-001
ENSP00000332049
ENST00000330540
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001878 [response to yeast]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002309 [T cell proliferation involved in immune response]
GO:0002668 [negative regulation of T cell anergy]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0032496 [response to lipopolysaccharide]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034341 [response to interferon-gamma]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042493 [response to drug]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071248 [cellular response to metal ion]
GO:0071345 [cellular response to cytokine stimulus]
Show all
 329 aa
37.7 kDa 		Yes 1
CD86-002
ENSP00000377248
ENST00000393627
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070062 [extracellular exosome]
Show all
 323 aa
37 kDa 		Yes 1
CD86-003
ENSP00000418988
ENST00000469710
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070062 [extracellular exosome]
Show all
 247 aa
28.4 kDa 		No 1
CD86-004
ENSP00000420230
ENST00000493101
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070062 [extracellular exosome]
Show all
 217 aa
24.8 kDa 		Yes 1
CD86-005
ENSP00000417195
ENST00000478741
H7C4F8 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 277 aa
31.4 kDa 		Yes 0
CD86-007
ENSP00000419116
ENST00000482356
C9JXS1 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 167 aa
19 kDa 		Yes 0
CD86-201
ENSP00000264468
ENST00000264468
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070062 [extracellular exosome]
Show all
 275 aa
31.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.