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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CEP70
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CEP70

Gene description

Centrosomal protein 70kDa

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA036941 , HPA036942
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in prostate cancer (unfavourable) and cervical cancer (favourable).
Prostate cancer p<0.001
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA036941
HPA036942

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant tissues showed weak to moderate cytoplasmic positivity. Most cases of malignant lymphomas and renal cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most of the malignant cells showed moderate cytoplasmic positivity with additional nuclear staining in several cases. Several cases of testicular, colorectal, ovarian and pancreatic cancers were strongly stained. Several malignant gliomas, lymphomas and renal cancers were negative or weakly stained.

GENE INFORMATION

Gene name

CEP70 (HGNC Symbol)

Synonyms

BITE, FLJ13036

Description

Centrosomal protein 70kDa (HGNC Symbol)

Entrez gene summary

Chromosome

3

Cytoband

q22.3

Chromosome location (bp)

138494344 - 138594538

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114107 (version 83.38)

Entrez gene

80321

UniProt

Q8NHQ1 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NHQ1

Antibodypedia

CEP70 antibodies

PROTEIN BROWSER

«
CEP70-001
CEP70-002
CEP70-003
CEP70-004
CEP70-006
CEP70-007
CEP70-009
CEP70-010
CEP70-011
CEP70-012
CEP70-013
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CEP70-001
ENSP00000264982
ENST00000264982
Q8NHQ1 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0031965 [nuclear membrane]
Show all
597 aa
69.8 kDa
No 0
CEP70-002
ENSP00000419743
ENST00000464035
Q8NHQ1 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0031965 [nuclear membrane]
Show all
212 aa
25 kDa
No 0
CEP70-003
ENSP00000417821
ENST00000489254
B7Z2D2 [Direct mapping]
Centrosomal protein of 70 kDa; cDNA FLJ60498, highly similar to Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0031965 [nuclear membrane]
Show all
445 aa
52 kDa
No 0
CEP70-004
ENSP00000419231
ENST00000484888
Q8NHQ1 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0031965 [nuclear membrane]
Show all
597 aa
69.8 kDa
No 0
CEP70-006
ENSP00000417465
ENST00000481834
Q8NHQ1 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0031965 [nuclear membrane]
Show all
554 aa
64.9 kDa
No 0
CEP70-007
ENSP00000419817
ENST00000470159
C9JZ04 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Show all
116 aa
13.6 kDa
No 0
CEP70-009
ENSP00000418878
ENST00000485115
C9J0F4 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Show all
23 aa
2.6 kDa
No 0
CEP70-010
ENSP00000419833
ENST00000474781
Q8NHQ1 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0031965 [nuclear membrane]
Show all
579 aa
67.8 kDa
No 0
CEP70-011
ENSP00000417819
ENST00000462419
C9J710 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Show all
259 aa
30.7 kDa
No 0
CEP70-012
ENSP00000418131
ENST00000468900
C9J966 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Show all
293 aa
34.8 kDa
No 0
CEP70-013
ENSP00000418552
ENST00000459695
H7C4Y6 [Direct mapping]
Centrosomal protein of 70 kDa
Show all
Predicted intracellular proteins
Show all
71 aa
8.5 kDa
No 0

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