Expression of CEP70 in cancer - Summary - The Human Protein Atlas

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CEP70

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CEP70
Gene description	Centrosomal protein 70kDa
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA036941 , HPA036942
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable) and cervical cancer (favourable).
Prostate cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036941	HPA036942

GENE INFORMATION
Gene name	CEP70 (HGNC Symbol)
Synonyms	BITE, FLJ13036
Description	Centrosomal protein 70kDa (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q22.3
Chromosome location (bp)	138494344 - 138594538
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114107 (version 83.38)
Entrez gene	80321
UniProt	Q8NHQ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NHQ1
Antibodypedia	CEP70 antibodies

PROTEIN BROWSER

CEP70-001	CEP70-002	CEP70-003	CEP70-004	CEP70-006	CEP70-007	CEP70-009	CEP70-010	CEP70-011	CEP70-012	CEP70-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP70-001 ENSP00000264982 ENST00000264982	Q8NHQ1 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] Show all	597 aa 69.8 kDa	No	0
CEP70-002 ENSP00000419743 ENST00000464035	Q8NHQ1 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] Show all	212 aa 25 kDa	No	0
CEP70-003 ENSP00000417821 ENST00000489254	B7Z2D2 [Direct mapping] Centrosomal protein of 70 kDa; cDNA FLJ60498, highly similar to Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0031965 [nuclear membrane] Show all	445 aa 52 kDa	No	0
CEP70-004 ENSP00000419231 ENST00000484888	Q8NHQ1 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] Show all	597 aa 69.8 kDa	No	0
CEP70-006 ENSP00000417465 ENST00000481834	Q8NHQ1 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] Show all	554 aa 64.9 kDa	No	0
CEP70-007 ENSP00000419817 ENST00000470159	C9JZ04 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Show all		116 aa 13.6 kDa	No	0
CEP70-009 ENSP00000418878 ENST00000485115	C9J0F4 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Show all		23 aa 2.6 kDa	No	0
CEP70-010 ENSP00000419833 ENST00000474781	Q8NHQ1 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] Show all	579 aa 67.8 kDa	No	0
CEP70-011 ENSP00000417819 ENST00000462419	C9J710 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Show all		259 aa 30.7 kDa	No	0
CEP70-012 ENSP00000418131 ENST00000468900	C9J966 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Show all		293 aa 34.8 kDa	No	0
CEP70-013 ENSP00000418552 ENST00000459695	H7C4Y6 [Direct mapping] Centrosomal protein of 70 kDa Show all	Predicted intracellular proteins Show all		71 aa 8.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.