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RBP2

GENERAL INFORMATION

Gene name

 RBP2

Gene description

 Retinol binding protein 2, cellular

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (stomach cancer)
HPA (cell line):Cell line enriched (CACO-2)
HPA (normal tissue):Group enriched (duodenum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in small intestine and duodenum.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA035866
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (stomach cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035866

GENE INFORMATION

Gene name

 RBP2 (HGNC Symbol)

Synonyms

 CRABP-II, CRBP2, CRBPII, RBPC2

Description

 Retinol binding protein 2, cellular (HGNC Symbol)

Entrez gene summary

 This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]

Chromosome

 3

Cytoband

 q23

Chromosome location (bp)

 139452884 - 139480747

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114113 (version 83.38)

Entrez gene

 5948

UniProt

 P50120 (UniProt - Evidence at protein level)

neXtProt

 NX_P50120

Antibodypedia

 RBP2 antibodies

PROTEIN BROWSER
RBP2-001
RBP2-002
RBP2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBP2-001
ENSP00000232217
ENST00000232217
P50120 [Direct mapping]
Retinol-binding protein 2
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Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001523 [retinoid metabolic process]
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0006810 [transport]
GO:0007603 [phototransduction, visible light]
GO:0008289 [lipid binding]
GO:0008544 [epidermis development]
GO:0016918 [retinal binding]
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 134 aa
15.7 kDa 		No 0
RBP2-002
ENSP00000424333
ENST00000511956
D6RB89 [Direct mapping]
Retinol-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0006776 [vitamin A metabolic process]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0016918 [retinal binding]
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 103 aa
12 kDa 		No 0
RBP2-003
ENSP00000421266
ENST00000506825
D6RGE6 [Direct mapping]
Retinol-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006776 [vitamin A metabolic process]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0016918 [retinal binding]
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 24 aa
2.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.