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RBP1

GENERAL INFORMATION

Gene name

 RBP1

Gene description

 Retinol binding protein 1, cellular

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (SH-SY5Y)
HPA (normal tissue):Tissue enhanced (fallopian tube, ovary)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in Leydig cells and ovarian stromal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity support the protein profile.

Reliability score

 Supported based on 3 antibodies.
HPA007338 , CAB018603 , CAB019276
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007338
CAB018603
CAB019276

GENE INFORMATION

Gene name

 RBP1 (HGNC Symbol)

Synonyms

 CRABP-I, CRBP, CRBP1, CRBPI, RBPC

Description

 Retinol binding protein 1, cellular (HGNC Symbol)

Entrez gene summary

 This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

 3

Cytoband

 q23

Chromosome location (bp)

 139517434 - 139539829

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114115 (version 83.38)

Entrez gene

 5947

UniProt

 P09455 (UniProt - Evidence at protein level)

neXtProt

 NX_P09455

Antibodypedia

 RBP1 antibodies

PROTEIN BROWSER
RBP1-001
RBP1-002
RBP1-003
RBP1-006
RBP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBP1-001
ENSP00000232219
ENST00000232219
A0A0A0MQT0 [Direct mapping]
Retinol binding protein 1, cellular; Retinol-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002138 [retinoic acid biosynthetic process]
GO:0005215 [transporter activity]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0019841 [retinol binding]
GO:0030852 [regulation of granulocyte differentiation]
GO:0033189 [response to vitamin A]
GO:0042572 [retinol metabolic process]
GO:0042573 [retinoic acid metabolic process]
GO:0044297 [cell body]
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 197 aa
22.3 kDa 		No 0
RBP1-002
ENSP00000429166
ENST00000492918
P09455 [Direct mapping]
Retinol-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0002138 [retinoic acid biosynthetic process]
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0006810 [transport]
GO:0007603 [phototransduction, visible light]
GO:0008289 [lipid binding]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
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 157 aa
17.5 kDa 		No 0
RBP1-003
ENSP00000424813
ENST00000483943
A0A0A0MTB9 [Direct mapping]
Retinol-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002138 [retinoic acid biosynthetic process]
GO:0005215 [transporter activity]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0006810 [transport]
GO:0008289 [lipid binding]
Show all
 91 aa
10.6 kDa 		No 0
RBP1-006
ENSP00000482165
ENST00000619087
P09455 [Direct mapping]
Retinol-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0002138 [retinoic acid biosynthetic process]
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0006810 [transport]
GO:0007603 [phototransduction, visible light]
GO:0008289 [lipid binding]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
Show all
 135 aa
15.9 kDa 		No 0
RBP1-201
ENSP00000477621
ENST00000617459
P09455 [Direct mapping]
Retinol-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0002138 [retinoic acid biosynthetic process]
GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005829 [cytosol]
GO:0006776 [vitamin A metabolic process]
GO:0006810 [transport]
GO:0007603 [phototransduction, visible light]
GO:0008289 [lipid binding]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
Show all
 153 aa
17.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.