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XRN1

GENERAL INFORMATION

Gene name

 XRN1

Gene description

 5'-3' exoribonuclease 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (RH-30)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA035005 , HPA035006
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035005
HPA035006

GENE INFORMATION

Gene name

 XRN1 (HGNC Symbol)

Synonyms

 SEP1

Description

 5'-3' exoribonuclease 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 3

Cytoband

 q23

Chromosome location (bp)

 142306607 - 142448062

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114127 (version 83.38)

Entrez gene

 54464

UniProt

 Q8IZH2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IZH2

Antibodypedia

 XRN1 antibodies

PROTEIN BROWSER
XRN1-001
XRN1-003
XRN1-004
XRN1-006
XRN1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XRN1-001
ENSP00000264951
ENST00000264951
Q8IZH2 [Direct mapping]
5'-3' exoribonuclease 1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008409 [5'-3' exonuclease activity]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016075 [rRNA catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0071028 [nuclear mRNA surveillance]
GO:0071044 [histone mRNA catabolic process]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 1706 aa
194.1 kDa 		No 0
XRN1-003
ENSP00000418404
ENST00000463916
Q8IZH2 [Direct mapping]
5'-3' exoribonuclease 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016075 [rRNA catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0071028 [nuclear mRNA surveillance]
GO:0071044 [histone mRNA catabolic process]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 459 aa
53.8 kDa 		No 0
XRN1-004
ENSP00000376707
ENST00000392981
Q8IZH2 [Direct mapping]
5'-3' exoribonuclease 1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008409 [5'-3' exonuclease activity]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016075 [rRNA catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0071028 [nuclear mRNA surveillance]
GO:0071044 [histone mRNA catabolic process]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 1694 aa
192.8 kDa 		No 0
XRN1-006
ENSP00000419683
ENST00000498077
H7C5E4 [Direct mapping]
5'-3' exoribonuclease 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 1160 aa
130.1 kDa 		No 0
XRN1-009
ENSP00000420634
ENST00000477237
C9JCZ8 [Direct mapping]
5'-3' exoribonuclease 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004527 [exonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 165 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.