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Most malignant tissues showed weak to moderate cytoplasmic immunoreactivity. Cases of prostate and liver cancers showed strong cytoplasmic staining.
GENE INFORMATION
Gene name
PDCD10 (HGNC Symbol)
Synonyms
CCM3, TFAR15
Description
Programmed cell death 10 (HGNC Symbol)
Entrez gene summary
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]