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FGF12

GENERAL INFORMATION

Gene name

 FGF12

Gene description

 Fibroblast growth factor 12

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adrenal gland, cerebral cortex, heart muscle)
GTEx:Tissue enhanced (adrenal gland, cerebral cortex, heart muscle)
FANTOM5:Group enriched (brain, caudate, cerebellum, heart muscle, hippocampus)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, cerebral cortex, heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, cerebral cortex, heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, heart muscle, hippocampus)

GENE INFORMATION

Gene name

 FGF12 (HGNC Symbol)

Synonyms

 FGF12B, FHF1

Description

 Fibroblast growth factor 12 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

Chromosome location (bp)

 192139395 - 192767764

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114279 (version 83.38)

Entrez gene

 2257

UniProt

 P61328 (UniProt - Evidence at protein level)

neXtProt

 NX_P61328

Antibodypedia

 FGF12 antibodies

PROTEIN BROWSER
FGF12-001
FGF12-002
FGF12-005
FGF12-006
FGF12-007
FGF12-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGF12-001
ENSP00000413496
ENST00000454309
P61328 [Direct mapping]
Fibroblast growth factor 12
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008344 [adult locomotory behavior]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010765 [positive regulation of sodium ion transport]
GO:0017080 [sodium channel regulator activity]
GO:0044325 [ion channel binding]
GO:0050905 [neuromuscular process]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
GO:2001258 [negative regulation of cation channel activity]
Show all
 243 aa
27.4 kDa 		No 0
FGF12-002
ENSP00000393686
ENST00000445105
P61328 [Direct mapping]
Fibroblast growth factor 12
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0017080 [sodium channel regulator activity]
GO:0044325 [ion channel binding]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 181 aa
20.4 kDa 		No 0
FGF12-005
ENSP00000395517
ENST00000418610
C9JIN3 [Direct mapping]
Fibroblast growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0008083 [growth factor activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 107 aa
12.2 kDa 		No 0
FGF12-006
ENSP00000410125
ENST00000430714
C9JEN8 [Direct mapping]
Fibroblast growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0008083 [growth factor activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 144 aa
16.2 kDa 		No 0
FGF12-007
ENSP00000412904
ENST00000448795
C9JUK8 [Direct mapping]
Fibroblast growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0008083 [growth factor activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
 141 aa
16 kDa 		No 0
FGF12-009
ENSP00000397635
ENST00000450716
P61328 [Direct mapping]
Fibroblast growth factor 12
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0017080 [sodium channel regulator activity]
GO:0044325 [ion channel binding]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 181 aa
20.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.