Fields »
ABOUT
HELP
BLOG
ECT2

GENERAL INFORMATION

Gene name

 ECT2

Gene description

 Epithelial cell transforming 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ECT2 (HGNC Symbol)

Synonyms

 ARHGEF31

Description

 Epithelial cell transforming 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 3

Cytoband

 q26.31

Chromosome location (bp)

 172750682 - 172821474

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114346 (version 83.38)

Entrez gene

 1894

UniProt

 Q9H8V3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H8V3

Antibodypedia

 ECT2 antibodies

PROTEIN BROWSER
«
ECT2-001
ECT2-002
ECT2-003
ECT2-004
ECT2-005
ECT2-007
ECT2-008
ECT2-009
ECT2-010
ECT2-013
ECT2-014
ECT2-015
ECT2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ECT2-001
ENSP00000232458
ENST00000232458
Q9H8V3 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0004871 [signal transducer activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0030496 [midbody]
GO:0031965 [nuclear membrane]
GO:0032147 [activation of protein kinase activity]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045859 [regulation of protein kinase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051260 [protein homooligomerization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070830 [bicellular tight junction assembly]
GO:0071277 [cellular response to calcium ion]
GO:0071479 [cellular response to ionizing radiation]
GO:0072686 [mitotic spindle]
GO:0090630 [activation of GTPase activity]
GO:0097149 [centralspindlin complex]
GO:0097190 [apoptotic signaling pathway]
Show all
 883 aa
100.1 kDa 		No 0
ECT2-002
ENSP00000412259
ENST00000441497
Q9H8V3 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0004871 [signal transducer activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0030496 [midbody]
GO:0031965 [nuclear membrane]
GO:0032147 [activation of protein kinase activity]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045859 [regulation of protein kinase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051260 [protein homooligomerization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070830 [bicellular tight junction assembly]
GO:0071277 [cellular response to calcium ion]
GO:0071479 [cellular response to ionizing radiation]
GO:0072686 [mitotic spindle]
GO:0090630 [activation of GTPase activity]
GO:0097149 [centralspindlin complex]
GO:0097190 [apoptotic signaling pathway]
Show all
 883 aa
100.1 kDa 		No 0
ECT2-003
ENSP00000376457
ENST00000392692
Q9H8V3 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0000910 [cytokinesis]
GO:0004871 [signal transducer activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0017048 [Rho GTPase binding]
GO:0030496 [midbody]
GO:0031965 [nuclear membrane]
GO:0032147 [activation of protein kinase activity]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045859 [regulation of protein kinase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051260 [protein homooligomerization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070830 [bicellular tight junction assembly]
GO:0071277 [cellular response to calcium ion]
GO:0071479 [cellular response to ionizing radiation]
GO:0072686 [mitotic spindle]
GO:0090630 [activation of GTPase activity]
GO:0097149 [centralspindlin complex]
GO:0097190 [apoptotic signaling pathway]
Show all
 914 aa
103.5 kDa 		No 0
ECT2-004
ENSP00000415876
ENST00000417960
Q9H8V3 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0004871 [signal transducer activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0030496 [midbody]
GO:0031965 [nuclear membrane]
GO:0032147 [activation of protein kinase activity]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045859 [regulation of protein kinase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051260 [protein homooligomerization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070830 [bicellular tight junction assembly]
GO:0071277 [cellular response to calcium ion]
GO:0071479 [cellular response to ionizing radiation]
GO:0072686 [mitotic spindle]
GO:0090630 [activation of GTPase activity]
GO:0097149 [centralspindlin complex]
GO:0097190 [apoptotic signaling pathway]
Show all
 882 aa
99.9 kDa 		No 0
ECT2-005
ENSP00000397788
ENST00000437296
H7C103 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0000910 [cytokinesis]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
Show all
 298 aa
33.4 kDa 		No 0
ECT2-007
ENSP00000391695
ENST00000366254
C9JB41 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 18 aa
1.9 kDa 		No 0
ECT2-008
ENSP00000412028
ENST00000415665
C9J1C4 [Direct mapping]
Protein ECT2
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0000910 [cytokinesis]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
Show all
 159 aa
17.8 kDa 		No 0
ECT2-009
ENSP00000389108
ENST00000438041
C9JTI2 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0000910 [cytokinesis]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
Show all
 150 aa
16.7 kDa 		No 0
ECT2-010
ENSP00000411674
ENST00000444250
H7C3G1 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0000910 [cytokinesis]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
Show all
 209 aa
23.9 kDa 		No 0
ECT2-013
ENSP00000412331
ENST00000426894
C9J0L6 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0000910 [cytokinesis]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
Show all
 106 aa
11.8 kDa 		No 0
ECT2-014
ENSP00000403446
ENST00000366090
C9JDV9 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0000910 [cytokinesis]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
Show all
 110 aa
12.2 kDa 		No 0
ECT2-015
ENSP00000403501
ENST00000428567
C9JDB4 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0000910 [cytokinesis]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
Show all
 204 aa
22.7 kDa 		No 0
ECT2-201
ENSP00000443160
ENST00000540509
Q9H8V3 [Direct mapping]
Protein ECT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0004871 [signal transducer activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0030496 [midbody]
GO:0031965 [nuclear membrane]
GO:0032147 [activation of protein kinase activity]
GO:0032154 [cleavage furrow]
GO:0032467 [positive regulation of cytokinesis]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045859 [regulation of protein kinase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051260 [protein homooligomerization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070830 [bicellular tight junction assembly]
GO:0071277 [cellular response to calcium ion]
GO:0071479 [cellular response to ionizing radiation]
GO:0072686 [mitotic spindle]
GO:0090630 [activation of GTPase activity]
GO:0097149 [centralspindlin complex]
GO:0097190 [apoptotic signaling pathway]
Show all
 883 aa
100.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.