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USP9Y

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GENERAL INFORMATION

Gene name

 USP9Y

Gene description

 Ubiquitin specific peptidase 9, Y-linked

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enhanced (RPTEC TERT1)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA057687
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPTEC TERT1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057687 Hep G2 Vesicles
HPA057687 RT4 Vesicles
HPA057687 U-2 OS Vesicles

GENE INFORMATION

Gene name

 USP9Y (HGNC Symbol)

Synonyms

 DFFRY

Description

 Ubiquitin specific peptidase 9, Y-linked (HGNC Symbol)

Entrez gene summary

 This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. [provided by RefSeq, Mar 2009]

Chromosome

 Y

Cytoband

 q11.221

Chromosome location (bp)

 12701231 - 12860839

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114374 (version 83.38)

Entrez gene

 8287

UniProt

 O00507 (UniProt - Evidence at transcript level)

neXtProt

 NX_O00507

Antibodypedia

 USP9Y antibodies

PROTEIN BROWSER
USP9Y-001
USP9Y-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP9Y-001
ENSP00000342812
ENST00000338981
O00507 [Direct mapping]
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005488 [binding]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0008234 [cysteine-type peptidase activity]
GO:0016477 [cell migration]
GO:0016579 [protein deubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070410 [co-SMAD binding]
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 2555 aa
291.1 kDa 		No 0
USP9Y-005
ENSP00000406876
ENST00000453031
H7C2M9 [Direct mapping]
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0016477 [cell migration]
GO:0016579 [protein deubiquitination]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
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 237 aa
26.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.