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HYAL1

GENERAL INFORMATION

Gene name

 HYAL1

Gene description

 Hyaluronoglucosaminidase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (liver, spleen)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA002112
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)

GENE INFORMATION

Gene name

 HYAL1 (HGNC Symbol)

Synonyms

 FUS2, HYAL-1, LUCA1, NAT6

Description

 Hyaluronoglucosaminidase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 50299889 - 50312381

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114378 (version 83.38)

Entrez gene

 3373

UniProt

 Q12794 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12794

Antibodypedia

 HYAL1 antibodies

PROTEIN BROWSER
HYAL1-001
HYAL1-002
HYAL1-003
HYAL1-004
HYAL1-005
HYAL1-006
HYAL1-007
HYAL1-008
HYAL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HYAL1-001
ENSP00000378576
ENST00000395144
Q12794 [Direct mapping]
Hyaluronidase-1
A0A024R2X3 [Target identity:100%; Query identity:100%]
Hyaluronidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0009615 [response to virus]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031410 [cytoplasmic vesicle]
GO:0036117 [hyaluranon cable]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045927 [positive regulation of growth]
GO:0046677 [response to antibiotic]
GO:0050501 [hyaluronan synthase activity]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051216 [cartilage development]
GO:0070062 [extracellular exosome]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071467 [cellular response to pH]
GO:0071493 [cellular response to UV-B]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 435 aa
48.4 kDa 		Yes 0
HYAL1-002
ENSP00000378575
ENST00000395143
Q12794 [Direct mapping]
Hyaluronidase-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0009615 [response to virus]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031410 [cytoplasmic vesicle]
GO:0036117 [hyaluranon cable]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045927 [positive regulation of growth]
GO:0046677 [response to antibiotic]
GO:0050501 [hyaluronan synthase activity]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051216 [cartilage development]
GO:0070062 [extracellular exosome]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071467 [cellular response to pH]
GO:0071493 [cellular response to UV-B]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 405 aa
45.1 kDa 		Yes 0
HYAL1-003
ENSP00000393358
ENST00000457214
Q12794 [Direct mapping]
Hyaluronidase-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0009615 [response to virus]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031410 [cytoplasmic vesicle]
GO:0036117 [hyaluranon cable]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045927 [positive regulation of growth]
GO:0046677 [response to antibiotic]
GO:0050501 [hyaluronan synthase activity]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051216 [cartilage development]
GO:0070062 [extracellular exosome]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071467 [cellular response to pH]
GO:0071493 [cellular response to UV-B]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 253 aa
28 kDa 		No 0
HYAL1-004
ENSP00000390149
ENST00000447605
Q12794 [Direct mapping]
Hyaluronidase-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0009615 [response to virus]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031410 [cytoplasmic vesicle]
GO:0036117 [hyaluranon cable]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045927 [positive regulation of growth]
GO:0046677 [response to antibiotic]
GO:0050501 [hyaluronan synthase activity]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051216 [cartilage development]
GO:0070062 [extracellular exosome]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071467 [cellular response to pH]
GO:0071493 [cellular response to UV-B]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 176 aa
19.4 kDa 		No 0
HYAL1-005
ENSP00000266031
ENST00000266031
Q12794 [Direct mapping]
Hyaluronidase-1
A0A024R2X3 [Target identity:100%; Query identity:100%]
Hyaluronidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0009615 [response to virus]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031410 [cytoplasmic vesicle]
GO:0036117 [hyaluranon cable]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045927 [positive regulation of growth]
GO:0046677 [response to antibiotic]
GO:0050501 [hyaluronan synthase activity]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051216 [cartilage development]
GO:0060272 [embryonic skeletal joint morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071467 [cellular response to pH]
GO:0071493 [cellular response to UV-B]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 435 aa
48.4 kDa 		Yes 0
HYAL1-006
ENSP00000346068
ENST00000320295
Q12794 [Direct mapping]
Hyaluronidase-1
A0A024R2X3 [Target identity:100%; Query identity:100%]
Hyaluronidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0009615 [response to virus]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031410 [cytoplasmic vesicle]
GO:0036117 [hyaluranon cable]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045927 [positive regulation of growth]
GO:0046677 [response to antibiotic]
GO:0050501 [hyaluronan synthase activity]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051216 [cartilage development]
GO:0070062 [extracellular exosome]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071467 [cellular response to pH]
GO:0071493 [cellular response to UV-B]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 435 aa
48.4 kDa 		Yes 0
HYAL1-007
ENSP00000394526
ENST00000418723
C9JRK1 [Direct mapping]
Hyaluronidase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005975 [carbohydrate metabolic process]
Show all
 103 aa
11.3 kDa 		Yes 0
HYAL1-008
ENSP00000391666
ENST00000452672
C9JB49 [Direct mapping]
Hyaluronidase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005975 [carbohydrate metabolic process]
Show all
 69 aa
7.6 kDa 		Yes 0
HYAL1-201
ENSP00000477903
ENST00000618175
Q12794 [Direct mapping]
Hyaluronidase-1
A0A024R2X3 [Target identity:100%; Query identity:100%]
Hyaluronidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004415 [hyalurononglucosaminidase activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006954 [inflammatory response]
GO:0008134 [transcription factor binding]
GO:0009615 [response to virus]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0030214 [hyaluronan catabolic process]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031410 [cytoplasmic vesicle]
GO:0036117 [hyaluranon cable]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045927 [positive regulation of growth]
GO:0046677 [response to antibiotic]
GO:0050501 [hyaluronan synthase activity]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051216 [cartilage development]
GO:0070062 [extracellular exosome]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071467 [cellular response to pH]
GO:0071493 [cellular response to UV-B]
GO:1900106 [positive regulation of hyaluranon cable assembly]
Show all
 435 aa
48.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.