Expression of BBX in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BBX
Gene description	Bobby sox homolog (Drosophila)
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	21
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in many tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA006049 , HPA050646
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA006049	HPA050646

GENE INFORMATION
Gene name	BBX (HGNC Symbol)
Synonyms	HBP2, HSPC339, MDS001
Description	Bobby sox homolog (Drosophila) (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q13.12
Chromosome location (bp)	107522936 - 107811324
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114439 (version 83.38)
Entrez gene	56987
UniProt	Q8WY36 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WY36
Antibodypedia	BBX antibodies

PROTEIN BROWSER

BBX-001	BBX-002	BBX-004	BBX-005	BBX-006	BBX-007	BBX-009	BBX-010	BBX-011	BBX-012	BBX-013	BBX-015	BBX-017	BBX-018	BBX-019	BBX-020	BBX-021	BBX-022	BBX-026	BBX-027	BBX-028

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BBX-001 ENSP00000408358 ENST00000415149	Q8WY36 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	911 aa 101.6 kDa	No	0
BBX-002 ENSP00000385317 ENST00000402543	C9JA69 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	891 aa 99.3 kDa	No	0
BBX-004 ENSP00000385518 ENST00000402163	C9J8D0 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	448 aa 50.7 kDa	No	0
BBX-005 ENSP00000385530 ENST00000406780	Q8WY36 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	911 aa 101.6 kDa	No	0
BBX-006 ENSP00000403860 ENST00000416476	Q8WY36 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	628 aa 71.5 kDa	No	0
BBX-007 ENSP00000319974 ENST00000325805	Q8WY36 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0060348 [bone development] Show all	941 aa 105.1 kDa	No	0
BBX-009 ENSP00000413320 ENST00000427402	C9JYU6 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		193 aa 22.3 kDa	No	0
BBX-010 ENSP00000392230 ENST00000431630	C9IYG9 [Direct mapping] HMG box transcription factor BBX Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.6 kDa	No	0
BBX-011 ENSP00000408297 ENST00000449335	C9JNU3 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 16.8 kDa	No	0
BBX-012 ENSP00000400543 ENST00000456817	C9IYS9 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 8.1 kDa	No	0
BBX-013 ENSP00000404654 ENST00000458458	C9JE62 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.3 kDa	No	0
BBX-015 ENSP00000413274 ENST00000456419	C9JZA0 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		205 aa 23.7 kDa	No	0
BBX-017 ENSP00000406554 ENST00000449271	C9J0J4 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 13.2 kDa	No	0
BBX-018 ENSP00000403806 ENST00000413213	C9JIZ2 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 17.4 kDa	No	0
BBX-019 ENSP00000412390 ENST00000425868	C9J067 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.7 kDa	No	0
BBX-020 ENSP00000407662 ENST00000449213	C9K0D1 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		159 aa 18.5 kDa	No	0
BBX-021 ENSP00000404943 ENST00000457496	C9JC04 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		85 aa 9.7 kDa	No	0
BBX-022 ENSP00000414673 ENST00000429270	C9JSH4 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		166 aa 19.2 kDa	No	0
BBX-026 ENSP00000401524 ENST00000458347	H7C1Q0 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 14.2 kDa	No	0
BBX-027 ENSP00000402372 ENST00000443253	H7C1U1 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		80 aa 9.1 kDa	No	0
BBX-028 ENSP00000396373 ENST00000454540	C9JD74 [Direct mapping] HMG box transcription factor BBX Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		13 aa 1.5 kDa	No	0