Fields »
ABOUT
HELP
BLOG
GNB4

GENERAL INFORMATION

Gene name

 GNB4

Gene description

 Guanine nucleotide binding protein (G protein), beta polypeptide 4

Protein class

 Disease related genes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA040736 , CAB018383 , CAB018737
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040736
CAB018383
CAB018737

GENE INFORMATION

Gene name

 GNB4

Synonyms

Description

 Guanine nucleotide binding protein (G protein), beta polypeptide 4 (HGNC Symbol)

Entrez gene summary

 Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q26.33

Chromosome location (bp)

 179396089 - 179451590

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114450 (version 83.38)

Entrez gene

 59345

UniProt

 Q9HAV0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HAV0

Antibodypedia

 GNB4 antibodies

PROTEIN BROWSER
GNB4-001
GNB4-003
GNB4-004
GNB4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNB4-001
ENSP00000232564
ENST00000232564
Q9HAV0 [Direct mapping]
Guanine nucleotide-binding protein subunit beta-4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0021762 [substantia nigra development]
GO:0032403 [protein complex binding]
GO:0043209 [myelin sheath]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 340 aa
37.6 kDa 		No 0
GNB4-003
ENSP00000419693
ENST00000468623
Q9HAV0 [Direct mapping]
Guanine nucleotide-binding protein subunit beta-4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0021762 [substantia nigra development]
GO:0032403 [protein complex binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 340 aa
37.6 kDa 		No 0
GNB4-004
ENSP00000420066
ENST00000466899
H7C5J5 [Direct mapping]
Guanine nucleotide-binding protein subunit beta-4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 165 aa
17.9 kDa 		No 0
GNB4-005
ENSP00000420606
ENST00000497513
C9JD14 [Direct mapping]
Guanine nucleotide-binding protein subunit beta-4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 79 aa
9.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.