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Rare cases of squamous cell carcinomas of skin and cervix showed moderate cytoplasmic staining. Few cases of melanoma exhibited weak nuclear positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
MORC1 (HGNC Symbol)
Synonyms
CT33, MORC, ZCW6
Description
MORC family CW-type zinc finger 1 (HGNC Symbol)
Entrez gene summary
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]