Cell atlas - UMPS - The Human Protein Atlas

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UMPS

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	UMPS
Gene description	Uridine monophosphate synthetase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA036178
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036178	A-431	Cytosol
	HPA036178	U-2 OS	Cytosol
	HPA036178	U-251 MG	Cytosol

GENE INFORMATION
Gene name	UMPS
Synonyms
Description	Uridine monophosphate synthetase (HGNC Symbol)
Entrez gene summary	This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Chromosome	3
Cytoband	q21.2
Chromosome location (bp)	124730366 - 124749273
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114491 (version 83.38)
Entrez gene	7372
UniProt	P11172 (UniProt - Evidence at protein level)
neXtProt	NX_P11172
Antibodypedia	UMPS antibodies

PROTEIN BROWSER

UMPS-001	UMPS-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UMPS-001 ENSP00000232607 ENST00000232607	P11172 [Direct mapping] Uridine 5'-monophosphate synthase Orotate phosphoribosyltransferase Orotidine 5'-phosphate decarboxylase A8K5J1 [Target identity:100%; Query identity:100%] Uridine monophosphate synthetase (Orotate phosphoribosyl transferase and orotidine-5'-decarboxylase), isoform CRA_b; Uridine monophosphate synthetase isoform A; cDNA FLJ75687, highly similar to Homo sapiens uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) (UMPS), mRNA Show all	Enzymes ENZYME proteins Transferases Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004588 [orotate phosphoribosyltransferase activity] GO:0004590 [orotidine-5'-phosphate decarboxylase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process] GO:0006222 [UMP biosynthetic process] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0008152 [metabolic process] GO:0009116 [nucleoside metabolic process] GO:0035690 [cellular response to drug] GO:0044205 ['de novo' UMP biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046134 [pyrimidine nucleoside biosynthetic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	480 aa 52.2 kDa	No	0
UMPS-201 ENSP00000486143 ENST00000628619	F2Z303 [Direct mapping] Uridine 5'-monophosphate synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.