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NCBP2

GENERAL INFORMATION

Gene name

 NCBP2

Gene description

 Nuclear cap binding protein subunit 2, 20kDa

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044850
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NCBP2 (HGNC Symbol)

Synonyms

 Cbc2, CBP20, NIP1

Description

 Nuclear cap binding protein subunit 2, 20kDa (HGNC Symbol)

Entrez gene summary

 The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q29

Chromosome location (bp)

 196935402 - 196942597

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114503 (version 83.38)

Entrez gene

 22916

UniProt

 P52298 (UniProt - Evidence at protein level)

neXtProt

 NX_P52298

Antibodypedia

 NCBP2 antibodies

PROTEIN BROWSER
NCBP2-001
NCBP2-004
NCBP2-006
NCBP2-007
NCBP2-010
NCBP2-011
NCBP2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCBP2-001
ENSP00000326806
ENST00000321256
P52298 [Direct mapping]
Nuclear cap-binding protein subunit 2
Show all
Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000339 [RNA cap binding]
GO:0000340 [RNA 7-methylguanosine cap binding]
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005845 [mRNA cap binding complex]
GO:0005846 [nuclear cap binding complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006406 [mRNA export from nucleus]
GO:0006408 [snRNA export from nucleus]
GO:0006446 [regulation of translational initiation]
GO:0008334 [histone mRNA metabolic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0031124 [mRNA 3'-end processing]
GO:0031442 [positive regulation of mRNA 3'-end processing]
GO:0034660 [ncRNA metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045292 [mRNA cis splicing, via spliceosome]
GO:0046833 [positive regulation of RNA export from nucleus]
GO:0050434 [positive regulation of viral transcription]
GO:0098789 [pre-mRNA cleavage required for polyadenylation]
Show all
 156 aa
18 kDa 		No 0
NCBP2-004
ENSP00000397619
ENST00000427641
P52298 [Direct mapping]
Nuclear cap-binding protein subunit 2
Show all
Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000339 [RNA cap binding]
GO:0000340 [RNA 7-methylguanosine cap binding]
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005845 [mRNA cap binding complex]
GO:0005846 [nuclear cap binding complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006406 [mRNA export from nucleus]
GO:0006408 [snRNA export from nucleus]
GO:0006446 [regulation of translational initiation]
GO:0008334 [histone mRNA metabolic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0031124 [mRNA 3'-end processing]
GO:0031442 [positive regulation of mRNA 3'-end processing]
GO:0034660 [ncRNA metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045292 [mRNA cis splicing, via spliceosome]
GO:0046833 [positive regulation of RNA export from nucleus]
GO:0050434 [positive regulation of viral transcription]
GO:0098789 [pre-mRNA cleavage required for polyadenylation]
Show all
 103 aa
11.9 kDa 		No 0
NCBP2-006
ENSP00000412785
ENST00000452404
P52298 [Direct mapping]
Nuclear cap-binding protein subunit 2
Show all
Transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000339 [RNA cap binding]
GO:0000340 [RNA 7-methylguanosine cap binding]
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005845 [mRNA cap binding complex]
GO:0005846 [nuclear cap binding complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006406 [mRNA export from nucleus]
GO:0006408 [snRNA export from nucleus]
GO:0006446 [regulation of translational initiation]
GO:0008334 [histone mRNA metabolic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0031124 [mRNA 3'-end processing]
GO:0031442 [positive regulation of mRNA 3'-end processing]
GO:0034660 [ncRNA metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045292 [mRNA cis splicing, via spliceosome]
GO:0046833 [positive regulation of RNA export from nucleus]
GO:0050434 [positive regulation of viral transcription]
GO:0098789 [pre-mRNA cleavage required for polyadenylation]
Show all
 138 aa
15.9 kDa 		No 0
NCBP2-007
ENSP00000413518
ENST00000447325
B3KSB0 [Direct mapping]
Nuclear cap binding protein subunit 2, 20kDa, isoform CRA_a; Nuclear cap-binding protein subunit 2; cDNA FLJ35897 fis, clone TESTI2009502, highly similar to Nuclear cap-binding protein subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000339 [RNA cap binding]
GO:0005654 [nucleoplasm]
GO:0005846 [nuclear cap binding complex]
GO:0045292 [mRNA cis splicing, via spliceosome]
Show all
 86 aa
9.9 kDa 		No 0
NCBP2-010
ENSP00000389315
ENST00000411704
C9JQX9 [Direct mapping]
Nuclear cap-binding protein subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000339 [RNA cap binding]
GO:0005654 [nucleoplasm]
GO:0005846 [nuclear cap binding complex]
GO:0045292 [mRNA cis splicing, via spliceosome]
Show all
 83 aa
9.5 kDa 		No 0
NCBP2-011
ENSP00000394105
ENST00000422610
B3KSB0 [Direct mapping]
Nuclear cap binding protein subunit 2, 20kDa, isoform CRA_a; Nuclear cap-binding protein subunit 2; cDNA FLJ35897 fis, clone TESTI2009502, highly similar to Nuclear cap-binding protein subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000339 [RNA cap binding]
GO:0005654 [nucleoplasm]
GO:0005846 [nuclear cap binding complex]
GO:0045292 [mRNA cis splicing, via spliceosome]
Show all
 86 aa
9.9 kDa 		No 0
NCBP2-012
ENSP00000402549
ENST00000455953
C9JKF4 [Direct mapping]
Nuclear cap-binding protein subunit 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005846 [nuclear cap binding complex]
Show all
 15 aa
1.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.