Expression of FRMD4B in cancer - Summary - The Human Protein Atlas

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FRMD4B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FRMD4B
Gene description	FERM domain containing 4B
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HUVEC TERT2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA009705
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA009705

GENE INFORMATION
Gene name	FRMD4B (HGNC Symbol)
Synonyms	GRSP1, KIAA1013
Description	FERM domain containing 4B (HGNC Symbol)
Entrez gene summary	This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]
Chromosome	3
Cytoband	p14.1
Chromosome location (bp)	69169990 - 69542583
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114541 (version 83.38)
Entrez gene	23150
UniProt	Q9Y2L6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2L6
Antibodypedia	FRMD4B antibodies

PROTEIN BROWSER

FRMD4B-001	FRMD4B-005	FRMD4B-006	FRMD4B-007	FRMD4B-011	FRMD4B-013	FRMD4B-014	FRMD4B-017	FRMD4B-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FRMD4B-001 ENSP00000381549 ENST00000398540	Q9Y2L6 [Direct mapping] FERM domain-containing protein 4B Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0090162 [establishment of epithelial cell polarity] Show all	1034 aa 118 kDa	No	0
FRMD4B-005 ENSP00000418682 ENST00000478263	E9PGA7 [Direct mapping] FERM domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		686 aa 77.3 kDa	No	0
FRMD4B-006 ENSP00000417765 ENST00000497880	C9J7M5 [Direct mapping] FERM domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] Show all	80 aa 9.5 kDa	No	0
FRMD4B-007 ENSP00000417550 ENST00000459638	C9JA15 [Direct mapping] FERM domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] Show all	113 aa 13.3 kDa	No	0
FRMD4B-011 ENSP00000418023 ENST00000460709	C9JAW0 [Direct mapping] FERM domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] Show all	142 aa 16.5 kDa	No	0
FRMD4B-013 ENSP00000418373 ENST00000473029	C9J6Q2 [Direct mapping] FERM domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] Show all	167 aa 19.3 kDa	No	0
FRMD4B-014 ENSP00000418962 ENST00000493880	H7C550 [Direct mapping] FERM domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] Show all	183 aa 21 kDa	No	0
FRMD4B-017 ENSP00000419869 ENST00000462512	C9JYK2 [Direct mapping] FERM domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] Show all	161 aa 18.8 kDa	No	0
FRMD4B-019 ENSP00000420735 ENST00000489817	C9JBX2 [Direct mapping] FERM domain-containing protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 2.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.