Fields »
ABOUT
HELP
BLOG
ATP6V1A

GENERAL INFORMATION

Gene name

 ATP6V1A

Gene description

 ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB006910
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB006910

GENE INFORMATION

Gene name

 ATP6V1A (HGNC Symbol)

Synonyms

 ATP6A1, ATP6V1A1, VA68, Vma1, VPP2

Description

 ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q13.31

Chromosome location (bp)

 113747019 - 113812056

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114573 (version 83.38)

Entrez gene

 523

UniProt

 P38606 (UniProt - Evidence at protein level)

neXtProt

 NX_P38606

Antibodypedia

 ATP6V1A antibodies

PROTEIN BROWSER
ATP6V1A-001
ATP6V1A-005
ATP6V1A-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V1A-001
ENSP00000273398
ENST00000273398
P38606 [Direct mapping]
V-type proton ATPase catalytic subunit A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0006810 [transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0008286 [insulin receptor signaling pathway]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016324 [apical plasma membrane]
GO:0016469 [proton-transporting two-sector ATPase complex]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0033180 [proton-transporting V-type ATPase, V1 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0043209 [myelin sheath]
GO:0046034 [ATP metabolic process]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
Show all
 617 aa
68.3 kDa 		No 0
ATP6V1A-005
ENSP00000419294
ENST00000475322
C9JVW8 [Direct mapping]
V-type proton ATPase catalytic subunit A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015992 [proton transport]
GO:0046034 [ATP metabolic process]
Show all
 221 aa
24.2 kDa 		No 0
ATP6V1A-006
ENSP00000417545
ENST00000496747
C9JA17 [Direct mapping]
V-type proton ATPase catalytic subunit A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015992 [proton transport]
GO:0046034 [ATP metabolic process]
Show all
 185 aa
20.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.