Expression of KLHL18 in cancer - Summary - The Human Protein Atlas

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KLHL18

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KLHL18
Gene description	Kelch-like family member 18
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA035027 , HPA035028
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035027	HPA035028

GENE INFORMATION
Gene name	KLHL18 (HGNC Symbol)
Synonyms	FLJ13703, KIAA0795
Description	Kelch-like family member 18 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	47282917 - 47346816
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114648 (version 83.38)
Entrez gene	23276
UniProt	O94889 (UniProt - Evidence at protein level)
neXtProt	NX_O94889
Antibodypedia	KLHL18 antibodies

PROTEIN BROWSER

KLHL18-001	KLHL18-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHL18-001 ENSP00000232766 ENST00000232766	O94889 [Direct mapping] Kelch-like protein 18 A0A024R2T4 [Target identity:100%; Query identity:100%] Kelch-like 18 (Drosophila), isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] Show all	574 aa 63.6 kDa	No	0
KLHL18-006 ENSP00000411839 ENST00000437353	C9J4G4 [Direct mapping] Kelch-like protein 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	147 aa 16.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.