Expression of MRPL3 in cancer - Summary - The Human Protein Atlas

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MRPL3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRPL3
Gene description	Mitochondrial ribosomal protein L3
Protein class	Disease related genes Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA043665 , HPA060132
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001 Pancreatic cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043665	HPA060132

GENE INFORMATION
Gene name	MRPL3 (HGNC Symbol)
Synonyms	MRL3, RPML3
Description	Mitochondrial ribosomal protein L3 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	131462212 - 131502983
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114686 (version 83.38)
Entrez gene	11222
UniProt	P09001 (UniProt - Evidence at protein level)
neXtProt	NX_P09001
Antibodypedia	MRPL3 antibodies

PROTEIN BROWSER

MRPL3-001	MRPL3-002	MRPL3-003	MRPL3-004	MRPL3-007	MRPL3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL3-001 ENSP00000264995 ENST00000264995	P09001 [Direct mapping] 39S ribosomal protein L3, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	348 aa 38.6 kDa	No	0
MRPL3-002 ENSP00000424107 ENST00000511168	H0Y9G6 [Direct mapping] 39S ribosomal protein L3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	363 aa 40.5 kDa	No	0
MRPL3-003 ENSP00000398536 ENST00000425847	E7ETU7 [Direct mapping] 39S ribosomal protein L3, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	375 aa 41.6 kDa	No	0
MRPL3-004 ENSP00000422622 ENST00000510154	D6RBQ5 [Direct mapping] 39S ribosomal protein L3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		28 aa 3.3 kDa	No	0
MRPL3-007 ENSP00000422419 ENST00000507669	D6RC14 [Direct mapping] 39S ribosomal protein L3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	155 aa 17.1 kDa	No	0
MRPL3-010 ENSP00000422035 ENST00000512877	E9PF06 [Direct mapping] 39S ribosomal protein L3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	176 aa 19.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.