Expression of PLSCR4 in cancer - Summary - The Human Protein Atlas

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PLSCR4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLSCR4
Gene description	Phospholipid scramblase 4
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, HUVEC TERT2, TIME)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including membrane.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA002276
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002276

GENE INFORMATION
Gene name	PLSCR4
Synonyms
Description	Phospholipid scramblase 4 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q24
Chromosome location (bp)	146192339 - 146251179
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114698 (version 83.38)
Entrez gene	57088
UniProt	Q9NRQ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRQ2
Antibodypedia	PLSCR4 antibodies

PROTEIN BROWSER

PLSCR4-001	PLSCR4-002	PLSCR4-003	PLSCR4-004	PLSCR4-005	PLSCR4-006	PLSCR4-007	PLSCR4-008	PLSCR4-010	PLSCR4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLSCR4-001 ENSP00000347038 ENST00000354952	Q9NRQ2 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0017121 [phospholipid scrambling] GO:0017124 [SH3 domain binding] GO:0017128 [phospholipid scramblase activity] GO:0019899 [enzyme binding] GO:0042609 [CD4 receptor binding] GO:0070062 [extracellular exosome] GO:0071222 [cellular response to lipopolysaccharide] Show all	329 aa 37 kDa	No	1
PLSCR4-002 ENSP00000415605 ENST00000433593	Q9NRQ2 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0017121 [phospholipid scrambling] GO:0017124 [SH3 domain binding] GO:0017128 [phospholipid scramblase activity] GO:0019899 [enzyme binding] GO:0042609 [CD4 receptor binding] GO:0070062 [extracellular exosome] Show all	224 aa 24.8 kDa	No	1
PLSCR4-003 ENSP00000419040 ENST00000493382	Q9NRQ2 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0017121 [phospholipid scrambling] GO:0017124 [SH3 domain binding] GO:0017128 [phospholipid scramblase activity] GO:0019899 [enzyme binding] GO:0042609 [CD4 receptor binding] GO:0070062 [extracellular exosome] Show all	329 aa 37 kDa	No	1
PLSCR4-004 ENSP00000399315 ENST00000446574	Q9NRQ2 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0017121 [phospholipid scrambling] GO:0017124 [SH3 domain binding] GO:0017128 [phospholipid scramblase activity] GO:0019899 [enzyme binding] GO:0042609 [CD4 receptor binding] GO:0070062 [extracellular exosome] Show all	329 aa 37 kDa	No	1
PLSCR4-005 ENSP00000417896 ENST00000460350	C9J6E1 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017121 [phospholipid scrambling] GO:0017128 [phospholipid scramblase activity] Show all	262 aa 29.4 kDa	No	0
PLSCR4-006 ENSP00000420385 ENST00000460885	C9JNW2 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017121 [phospholipid scrambling] GO:0017128 [phospholipid scramblase activity] Show all	147 aa 15.9 kDa	No	0
PLSCR4-007 ENSP00000418173 ENST00000476202	C9J916 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017121 [phospholipid scrambling] GO:0017128 [phospholipid scramblase activity] Show all	208 aa 23.4 kDa	No	0
PLSCR4-008 ENSP00000418419 ENST00000481701	C9J664 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017121 [phospholipid scrambling] GO:0017128 [phospholipid scramblase activity] Show all	142 aa 15.5 kDa	No	0
PLSCR4-010 ENSP00000417248 ENST00000498625	C9J3P9 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017121 [phospholipid scrambling] GO:0017128 [phospholipid scramblase activity] Show all	98 aa 10.4 kDa	No	0
PLSCR4-201 ENSP00000372561 ENST00000383083	E9PHR9 [Direct mapping] Phospholipid scramblase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0017121 [phospholipid scrambling] GO:0017128 [phospholipid scramblase activity] Show all	239 aa 26.2 kDa	No	1

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