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MAPKAPK3

GENERAL INFORMATION

Gene name

 MAPKAPK3

Gene description

 Mitogen-activated protein kinase-activated protein kinase 3

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MAPKAPK3 (HGNC Symbol)

Synonyms

 3pK, MAPKAP3

Description

 Mitogen-activated protein kinase-activated protein kinase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Chromosome

 3

Cytoband

 p21.2

Chromosome location (bp)

 50611520 - 50649297

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114738 (version 83.38)

Entrez gene

 7867

UniProt

 Q16644 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16644

Antibodypedia

 MAPKAPK3 antibodies

PROTEIN BROWSER
MAPKAPK3-001
MAPKAPK3-002
MAPKAPK3-005
MAPKAPK3-006
MAPKAPK3-007
MAPKAPK3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPKAPK3-001
ENSP00000350639
ENST00000357955
Q16644 [Direct mapping]
MAP kinase-activated protein kinase 3
A0A024R2W7 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase-activated protein kinase 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0031965 [nuclear membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0034097 [response to cytokine]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0044351 [macropinocytosis]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051403 [stress-activated MAPK cascade]
Show all
 382 aa
43 kDa 		No 1
MAPKAPK3-002
ENSP00000396467
ENST00000446044
Q16644 [Direct mapping]
MAP kinase-activated protein kinase 3
A0A024R2W7 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase-activated protein kinase 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0031965 [nuclear membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0034097 [response to cytokine]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0044351 [macropinocytosis]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051403 [stress-activated MAPK cascade]
Show all
 382 aa
43 kDa 		No 1
MAPKAPK3-005
ENSP00000410970
ENST00000430409
C9J8E1 [Direct mapping]
MAP kinase-activated protein kinase 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0002224 [toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004871 [signal transducer activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 332 aa
37.4 kDa 		No 1
MAPKAPK3-006
ENSP00000402045
ENST00000457064
C9JPW3 [Direct mapping]
MAP kinase-activated protein kinase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0002224 [toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004871 [signal transducer activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 119 aa
12.9 kDa 		No 0
MAPKAPK3-007
ENSP00000394894
ENST00000451680
H7C0G6 [Direct mapping]
MAP kinase-activated protein kinase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0002224 [toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004871 [signal transducer activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 97 aa
11 kDa 		No 0
MAPKAPK3-201
ENSP00000478922
ENST00000621469
Q16644 [Direct mapping]
MAP kinase-activated protein kinase 3
A0A024R2W7 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase-activated protein kinase 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0031965 [nuclear membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0034097 [response to cytokine]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0044351 [macropinocytosis]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051403 [stress-activated MAPK cascade]
Show all
 382 aa
43 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.