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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACVR2B
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACVR2B

Gene description

Activin A receptor, type IIB

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, NTERA-2)
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including basal cells in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB025115
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB025115

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were mainly negative. Several cases of lymphomas, testicular, breast and renal cancers showed moderate cytoplasmic immunoreactivity.

GENE INFORMATION

Gene name

ACVR2B (HGNC Symbol)

Synonyms

ActR-IIB

Description

Activin A receptor, type IIB (HGNC Symbol)

Entrez gene summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p22.2

Chromosome location (bp)

38453851 - 38493142

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114739 (version 83.38)

Entrez gene

93

UniProt

Q13705 (UniProt - Evidence at protein level)

neXtProt

NX_Q13705

Antibodypedia

ACVR2B antibodies

PROTEIN BROWSER

ACVR2B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR2B-001
ENSP00000340361
ENST00000352511
Q13705 [Direct mapping]
Activin receptor type-2B
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001501 [skeletal system development]
GO:0001702 [gastrulation with mouth forming second]
GO:0001822 [kidney development]
GO:0001946 [lymphangiogenesis]
GO:0001974 [blood vessel remodeling]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007368 [determination of left/right symmetry]
GO:0007389 [pattern specification process]
GO:0007498 [mesoderm development]
GO:0007507 [heart development]
GO:0009749 [response to glucose]
GO:0009791 [post-embryonic development]
GO:0009952 [anterior/posterior pattern specification]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
GO:0016362 [activin receptor activity, type II]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030073 [insulin secretion]
GO:0030324 [lung development]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0031016 [pancreas development]
GO:0032147 [activation of protein kinase activity]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0035265 [organ growth]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043234 [protein complex]
GO:0043235 [receptor complex]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0048617 [embryonic foregut morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0060021 [palate development]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060840 [artery development]
GO:0060841 [venous blood vessel development]
GO:0061298 [retina vasculature development in camera-type eye]
Show all
512 aa
57.7 kDa
Yes 1

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