Expression of COMMD2 in cancer - Summary - The Human Protein Atlas

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COMMD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COMMD2
Gene description	COMM domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA044190
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and liver cancer (unfavourable).
Pancreatic cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044190

GENE INFORMATION
Gene name	COMMD2 (HGNC Symbol)
Synonyms	HSPC042
Description	COMM domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q25.1
Chromosome location (bp)	149738470 - 149752499
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114744 (version 83.38)
Entrez gene	51122
UniProt	Q86X83 (UniProt - Evidence at protein level)
neXtProt	NX_Q86X83
Antibodypedia	COMMD2 antibodies

PROTEIN BROWSER

COMMD2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COMMD2-001 ENSP00000419475 ENST00000473414	Q86X83 [Direct mapping] COMM domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	199 aa 22.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.