Expression of GORASP1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GORASP1

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GORASP1
Gene description	Golgi reassembly stacking protein 1, 65kDa
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA056283
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056283

GENE INFORMATION
Gene name	GORASP1 (HGNC Symbol)
Synonyms	FLJ23443, GOLPH5, GRASP65, P65
Description	Golgi reassembly stacking protein 1, 65kDa (HGNC Symbol)
Entrez gene summary	The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	39096659 - 39108363
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114745 (version 83.38)
Entrez gene	64689
UniProt	Q9BQQ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQQ3
Antibodypedia	GORASP1 antibodies

PROTEIN BROWSER

GORASP1-001	GORASP1-002	GORASP1-004	GORASP1-009	GORASP1-021	GORASP1-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GORASP1-001 ENSP00000313869 ENST00000319283	Q9BQQ3 [Direct mapping] Golgi reassembly-stacking protein 1 A0A024R2U5 [Target identity:100%; Query identity:100%] Golgi reassembly stacking protein 1, 65kDa, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0006487 [protein N-linked glycosylation] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007030 [Golgi organization] GO:0015031 [protein transport] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0050774 [negative regulation of dendrite morphogenesis] GO:0061024 [membrane organization] Show all	440 aa 46.5 kDa	No	0
GORASP1-002 ENSP00000419123 ENST00000479927	B4E1H8 [Direct mapping] Golgi reassembly-stacking protein 1; cDNA FLJ58222, highly similar to Golgi reassembly-stacking protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	345 aa 35.7 kDa	No	0
GORASP1-004 ENSP00000395709 ENST00000422110	B3KPY8 [Direct mapping] Golgi reassembly stacking protein 1, 65kDa, isoform CRA_f; Golgi reassembly-stacking protein 1; cDNA FLJ32481 fis, clone SKNMC2001113, moderately similar to Golgi reassembly-stacking protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	285 aa 29.2 kDa	No	0
GORASP1-009 ENSP00000411104 ENST00000441081	C9J9V9 [Direct mapping] Golgi reassembly-stacking protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	89 aa 9.8 kDa	No	0
GORASP1-021 ENSP00000392993 ENST00000437458	C9J0V5 [Direct mapping] Golgi reassembly-stacking protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	193 aa 21.6 kDa	No	0
GORASP1-022 ENSP00000405976 ENST00000416741	C9J5S6 [Direct mapping] Golgi reassembly-stacking protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	70 aa 7.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.