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ABHD14B

GENERAL INFORMATION

Gene name

 ABHD14B

Gene description

 Abhydrolase domain containing 14B

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA036444 , HPA036642
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036444
HPA036642

GENE INFORMATION

Gene name

 ABHD14B (HGNC Symbol)

Synonyms

 CIB, MGC15429

Description

 Abhydrolase domain containing 14B (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 p21.2

Chromosome location (bp)

 51968510 - 51983409

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114779 (version 83.38)

Entrez gene

 84836

UniProt

 Q96IU4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96IU4

Antibodypedia

 ABHD14B antibodies

PROTEIN BROWSER
ABHD14B-001
ABHD14B-002
ABHD14B-004
ABHD14B-005
ABHD14B-008
ABHD14B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABHD14B-001
ENSP00000378455
ENST00000395008
Q96IU4 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 14B
V9HW87 [Target identity:100%; Query identity:100%]
Abhydrolase domain containing 14B, isoform CRA_a; Epididymis secretory protein Li 299
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0016787 [hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0070062 [extracellular exosome]
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 210 aa
22.3 kDa 		No 0
ABHD14B-002
ENSP00000354841
ENST00000361143
Q96IU4 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 14B
V9HW87 [Target identity:100%; Query identity:100%]
Abhydrolase domain containing 14B, isoform CRA_a; Epididymis secretory protein Li 299
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0016787 [hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0070062 [extracellular exosome]
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 210 aa
22.3 kDa 		No 0
ABHD14B-004
ENSP00000417564
ENST00000461108
B4DQI4 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 14B; cDNA FLJ52723, highly similar to Abhydrolase domain-containing protein 14B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 188 aa
19.8 kDa 		No 0
ABHD14B-005
ENSP00000420065
ENST00000483233
Q96IU4 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 14B
V9HW87 [Target identity:100%; Query identity:100%]
Abhydrolase domain containing 14B, isoform CRA_a; Epididymis secretory protein Li 299
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0016787 [hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 210 aa
22.3 kDa 		No 0
ABHD14B-008
ENSP00000433388
ENST00000525795
Q96IU4 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 14B
V9HW87 [Target identity:100%; Query identity:100%]
Abhydrolase domain containing 14B, isoform CRA_a; Epididymis secretory protein Li 299
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0016787 [hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 210 aa
22.3 kDa 		No 0
ABHD14B-201
ENSP00000318248
ENST00000315877
F8W9U3 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 14B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
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 208 aa
22.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.