Expression of SSR3 in cancer - Summary - The Human Protein Atlas

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SSR3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SSR3
Gene description	Signal sequence receptor, gamma (translocon-associated protein gamma)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA014906
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and head and neck cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014906

GENE INFORMATION
Gene name	SSR3 (HGNC Symbol)
Synonyms	TRAPG
Description	Signal sequence receptor, gamma (translocon-associated protein gamma) (HGNC Symbol)
Entrez gene summary	The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
Chromosome	3
Cytoband	q25.31
Chromosome location (bp)	156540140 - 156555184
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114850 (version 83.38)
Entrez gene	6747
UniProt	Q9UNL2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNL2
Antibodypedia	SSR3 antibodies

PROTEIN BROWSER

SSR3-001	SSR3-002	SSR3-003	SSR3-005	SSR3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSR3-001 ENSP00000265044 ENST00000265044	Q9UNL2 [Direct mapping] Translocon-associated protein subunit gamma Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005784 [Sec61 translocon complex] GO:0006412 [translation] GO:0006613 [cotranslational protein targeting to membrane] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0010467 [gene expression] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0044267 [cellular protein metabolic process] Show all	185 aa 21.1 kDa	No	3
SSR3-002 ENSP00000420641 ENST00000467789	Q9UNL2 [Direct mapping] Translocon-associated protein subunit gamma Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005784 [Sec61 translocon complex] GO:0006412 [translation] GO:0006613 [cotranslational protein targeting to membrane] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0010467 [gene expression] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0044267 [cellular protein metabolic process] Show all	198 aa 22.6 kDa	No	3
SSR3-003 ENSP00000417530 ENST00000476217	C9JA28 [Direct mapping] Translocon-associated protein subunit gamma Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005784 [Sec61 translocon complex] GO:0006613 [cotranslational protein targeting to membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	174 aa 20.2 kDa	No	3
SSR3-005 ENSP00000417306 ENST00000463503	C9J365 [Direct mapping] Translocon-associated protein subunit gamma Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005784 [Sec61 translocon complex] GO:0006613 [cotranslational protein targeting to membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	133 aa 15.1 kDa	No	2
SSR3-006 ENSP00000420087 ENST00000496050	C9J365 [Direct mapping] Translocon-associated protein subunit gamma Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005784 [Sec61 translocon complex] GO:0006613 [cotranslational protein targeting to membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	133 aa 15.1 kDa	No	2

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The Human Protein Atlas

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