Expression of ADAM23 in cancer - Summary - The Human Protein Atlas

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ADAM23

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAM23
Gene description	ADAM metallopeptidase domain 23
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (RH-30, RPMI-8226)
HPA (normal tissue):	Group enriched (cerebral cortex, parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression and plasma positivity.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 2 antibodies. HPA012130 , CAB033276
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012130	CAB033276

GENE INFORMATION
Gene name	ADAM23 (HGNC Symbol)
Synonyms	MDC3
Description	ADAM metallopeptidase domain 23 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]
Chromosome	2
Cytoband	q33.3
Chromosome location (bp)	206443539 - 206621130
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114948 (version 83.38)
Entrez gene	8745
UniProt	O75077 (UniProt - Evidence at protein level)
neXtProt	NX_O75077
Antibodypedia	ADAM23 antibodies

PROTEIN BROWSER

ADAM23-001	ADAM23-002	ADAM23-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM23-001 ENSP00000264377 ENST00000264377	O75077 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 23 A0A024R3W8 [Target identity:100%; Query identity:100%] ADAM metallopeptidase domain 23, isoform CRA_a Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	832 aa 91.9 kDa	Yes	1
ADAM23-002 ENSP00000363536 ENST00000374415	E7EWD3 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 23 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	832 aa 92 kDa	Yes	1
ADAM23-003 ENSP00000406827 ENST00000444281	H7C2M6 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	107 aa 11.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.