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CCL20

GENERAL INFORMATION

Gene name

 CCL20

Gene description

 Chemokine (C-C motif) ligand 20

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (gallbladder, tonsil)
GTEx:Tissue enhanced (lung, small intestine)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 CCL20 (HGNC Symbol)

Synonyms

 CKb4, exodus-1, LARC, MIP-3a, SCYA20, ST38

Description

 Chemokine (C-C motif) ligand 20 (HGNC Symbol)

Entrez gene summary

 This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

 2

Cytoband

 q36.3

Chromosome location (bp)

 227813842 - 227817564

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115009 (version 83.38)

Entrez gene

 6364

UniProt

 P78556 (UniProt - Evidence at protein level)

neXtProt

 NX_P78556

Antibodypedia

 CCL20 antibodies

PROTEIN BROWSER
CCL20-001
CCL20-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL20-001
ENSP00000386273
ENST00000409189
P78556 [Direct mapping]
C-C motif chemokine 20 CCL20(1-67) CCL20(1-64) CCL20(2-70)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0030593 [neutrophil chemotaxis]
GO:0042742 [defense response to bacterium]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048247 [lymphocyte chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:2000406 [positive regulation of T cell migration]
Show all
 95 aa
10.7 kDa 		Yes 0
CCL20-004
ENSP00000351671
ENST00000358813
P78556 [Direct mapping]
C-C motif chemokine 20 CCL20(1-67) CCL20(1-64) CCL20(2-70)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0030593 [neutrophil chemotaxis]
GO:0042060 [wound healing]
GO:0042742 [defense response to bacterium]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048247 [lymphocyte chemotaxis]
GO:0050726 [positive regulation of interleukin-1 alpha biosynthetic process]
GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0071310 [cellular response to organic substance]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:2000406 [positive regulation of T cell migration]
Show all
 96 aa
10.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.