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CENPA

GENERAL INFORMATION

Gene name

 CENPA

Gene description

 Centromere protein A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
CAB008371
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Esophagus
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CENPA (HGNC Symbol)

Synonyms

 CenH3, CENP-A

Description

 Centromere protein A (HGNC Symbol)

Entrez gene summary

 Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 26764289 - 26801067

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115163 (version 83.38)

Entrez gene

 1058

UniProt

 P49450 (UniProt - Evidence at protein level)

neXtProt

 NX_P49450

Antibodypedia

 CENPA antibodies

PROTEIN BROWSER
CENPA-001
CENPA-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CENPA-001
ENSP00000336868
ENST00000335756
P49450 [Direct mapping]
Histone H3-like centromeric protein A
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000778 [condensed nuclear chromosome kinetochore]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000786 [nucleosome]
GO:0000939 [condensed chromosome inner kinetochore]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016032 [viral process]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0046982 [protein heterodimerization activity]
GO:0051382 [kinetochore assembly]
GO:0071459 [protein localization to chromosome, centromeric region]
Show all
 140 aa
16 kDa 		No 0
CENPA-006
ENSP00000233505
ENST00000233505
P49450 [Direct mapping]
Histone H3-like centromeric protein A
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000778 [condensed nuclear chromosome kinetochore]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016032 [viral process]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0046982 [protein heterodimerization activity]
GO:0051382 [kinetochore assembly]
GO:0071459 [protein localization to chromosome, centromeric region]
Show all
 114 aa
13 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.