We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A majority of cancer tissues showed weak to moderate nuclear immunoreactivity, often accompanied with cytoplasmic staining of weaker intensity. Strong positivity was observed in some gliomas and testicular cancers.
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]
Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006303 [double-strand break repair via nonhomologous end joining] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006595 [polyamine metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008237 [metallopeptidase activity] GO:0008286 [insulin receptor signaling pathway] GO:0008541 [proteasome regulatory particle, lid subcomplex] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010467 [gene expression] GO:0010950 [positive regulation of endopeptidase activity] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0022624 [proteasome accessory complex] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031597 [cytosolic proteasome complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034641 [cellular nitrogen compound metabolic process] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043488 [regulation of mRNA stability] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045471 [response to ethanol] GO:0046872 [metal ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050852 [T cell receptor signaling pathway] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0061133 [endopeptidase activator activity] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0070062 [extracellular exosome] GO:0070536 [protein K63-linked deubiquitination] GO:0070628 [proteasome binding] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway]