Expression of ASB3 in cancer - Summary - The Human Protein Atlas

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ASB3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASB3
Gene description	Ankyrin repeat and SOCS box containing 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA003940
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003940

GENE INFORMATION
Gene name	ASB3 (HGNC Symbol)
Synonyms	ASB-3
Description	Ankyrin repeat and SOCS box containing 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]
Chromosome	2
Cytoband	p16.2
Chromosome location (bp)	53532672 - 53787610
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115239 (version 83.38)
Entrez gene	51130
UniProt	Q9Y575 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y575
Antibodypedia	ASB3 antibodies

PROTEIN BROWSER

ASB3-001	ASB3-002	ASB3-003	ASB3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASB3-001 ENSP00000263634 ENST00000263634	Q9Y575 [Target identity:100%; Query identity:100%] Ankyrin repeat and SOCS box protein 3 A0A0A6YY97 [Direct mapping] Protein GPR75-ASB3 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	518 aa 57.7 kDa	No	0
ASB3-002 ENSP00000378206 ENST00000394717		THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0035556 [intracellular signal transduction] Show all	445 aa 49.6 kDa	No	0
ASB3-003 ENSP00000384728 ENST00000406687		THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0035556 [intracellular signal transduction] Show all	445 aa 49.6 kDa	No	0
ASB3-006 ENSP00000385137 ENST00000406053	H7BYZ6 [Direct mapping] Protein GPR75-ASB3 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	477 aa 52.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.