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PPM1G

GENERAL INFORMATION

Gene name

 PPM1G

Gene description

 Protein phosphatase, Mg2+/Mn2+ dependent, 1G

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Tissue enriched (testis)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA035530 , HPA035531
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPM1G (HGNC Symbol)

Synonyms

 PP2CG, PP2Cgamma

Description

 Protein phosphatase, Mg2+/Mn2+ dependent, 1G (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 27381194 - 27409687

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115241 (version 83.38)

Entrez gene

 5496

UniProt

 O15355 (UniProt - Evidence at protein level)

neXtProt

 NX_O15355

Antibodypedia

 PPM1G antibodies

PROTEIN BROWSER
PPM1G-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPM1G-001
ENSP00000342778
ENST00000344034
O15355 [Direct mapping]
Protein phosphatase 1G
Q6IAU5 [Target identity:100%; Query identity:100%]
PPM1G protein; Protein phosphatase 1G (Formerly 2C), magnesium-dependent, gamma isoform; Putative uncharacterized protein PPM1G
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0007050 [cell cycle arrest]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0043169 [cation binding]
GO:0046872 [metal ion binding]
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 546 aa
59.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.