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APC2

GENERAL INFORMATION

Gene name

 APC2

Gene description

 Adenomatosis polyposis coli 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION

Gene name

 APC2 (HGNC Symbol)

Synonyms

 APCL

Description

 Adenomatosis polyposis coli 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1446302 - 1473244

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115266 (version 83.38)

Entrez gene

 10297

UniProt

 O95996 (UniProt - Evidence at protein level)

neXtProt

 NX_O95996

Antibodypedia

 APC2 antibodies

PROTEIN BROWSER
APC2-001
APC2-004
APC2-005
APC2-006
APC2-007
APC2-008
APC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APC2-001
ENSP00000467073
ENST00000590469
A0A0C4DGQ0 [Direct mapping]
Adenomatous polyposis coli protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0008013 [beta-catenin binding]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 702 aa
77.7 kDa 		No 0
APC2-004
ENSP00000442954
ENST00000535453
O95996 [Direct mapping]
Adenomatous polyposis coli protein 2
Show all
Predicted intracellular proteins
Show all
GO:0000139 [Golgi membrane]
GO:0001708 [cell fate specification]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005881 [cytoplasmic microtubule]
GO:0005884 [actin filament]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007389 [pattern specification process]
GO:0008013 [beta-catenin binding]
GO:0008017 [microtubule binding]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0016055 [Wnt signaling pathway]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0030877 [beta-catenin destruction complex]
GO:0031258 [lamellipodium membrane]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0045295 [gamma-catenin binding]
GO:0045595 [regulation of cell differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 2303 aa
243.9 kDa 		No 0
APC2-005
ENSP00000466803
ENST00000587869
K7EN62 [Direct mapping]
Adenomatous polyposis coli protein 2
Show all
Predicted intracellular proteins
Show all
GO:0008013 [beta-catenin binding]
GO:0030178 [negative regulation of Wnt signaling pathway]
Show all
 170 aa
19.3 kDa 		No 0
APC2-006
ENSP00000238483
ENST00000238483
B5MDS5 [Direct mapping]
Adenomatous polyposis coli protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0008013 [beta-catenin binding]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 731 aa
80.6 kDa 		No 0
APC2-007
ENSP00000466173
ENST00000590877
K7ELQ3 [Direct mapping]
Adenomatous polyposis coli protein 2
Show all
Predicted intracellular proteins
Show all
GO:0008013 [beta-catenin binding]
GO:0030178 [negative regulation of Wnt signaling pathway]
Show all
 194 aa
22.2 kDa 		No 0
APC2-008
ENSP00000468199
ENST00000587149
K7ERC5 [Direct mapping]
Adenomatous polyposis coli protein 2
Show all
Predicted intracellular proteins
Show all
GO:0008013 [beta-catenin binding]
GO:0030178 [negative regulation of Wnt signaling pathway]
Show all
 138 aa
15.3 kDa 		No 0
APC2-201
ENSP00000233607
ENST00000233607
O95996 [Direct mapping]
Adenomatous polyposis coli protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001708 [cell fate specification]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005881 [cytoplasmic microtubule]
GO:0005884 [actin filament]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007389 [pattern specification process]
GO:0008013 [beta-catenin binding]
GO:0008017 [microtubule binding]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0016055 [Wnt signaling pathway]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0030877 [beta-catenin destruction complex]
GO:0031258 [lamellipodium membrane]
GO:0035414 [negative regulation of catenin import into nucleus]
GO:0045295 [gamma-catenin binding]
GO:0045595 [regulation of cell differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 2303 aa
243.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.