Expression of RPS15 in cancer - Summary - The Human Protein Atlas

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RPS15

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RPS15
Gene description	Ribosomal protein S15
Protein class	Cancer-related genes Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA054510 , HPA057793
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054510	HPA057793

GENE INFORMATION
Gene name	RPS15 (HGNC Symbol)
Synonyms	MGC111130, RIG, S15
Description	Ribosomal protein S15 (HGNC Symbol)
Entrez gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1438358 - 1440494
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115268 (version 83.38)
Entrez gene	6209
UniProt	P62841 (UniProt - Evidence at protein level)
neXtProt	NX_P62841
Antibodypedia	RPS15 antibodies

PROTEIN BROWSER

RPS15-001	RPS15-002	RPS15-004	RPS15-005	RPS15-006	RPS15-007	RPS15-008	RPS15-009	RPS15-010	RPS15-011	RPS15-012	RPS15-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPS15-001 ENSP00000467466 ENST00000592588	P62841 [Direct mapping] 40S ribosomal protein S15 Show all	Ribosomal proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0000056 [ribosomal small subunit export from nucleus] GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0001649 [osteoblast differentiation] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005925 [focal adhesion] GO:0006364 [rRNA processing] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0010467 [gene expression] GO:0015935 [small ribosomal subunit] GO:0016020 [membrane] GO:0016032 [viral process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0022627 [cytosolic small ribosomal subunit] GO:0042274 [ribosomal small subunit biogenesis] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] Show all	145 aa 17 kDa	No	0
RPS15-002 ENSP00000466010 ENST00000593052	K7ELC2 [Direct mapping] 40S ribosomal protein S15 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	152 aa 17.7 kDa	No	0
RPS15-004 ENSP00000467855 ENST00000589656	K7EQJ5 [Direct mapping] 40S ribosomal protein S15 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003735 [structural constituent of ribosome] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	141 aa 16.6 kDa	No	0
RPS15-005 ENSP00000475096 ENST00000586656	S4R456 [Direct mapping] 40S ribosomal protein S15 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	68 aa 8 kDa	No	0
RPS15-006 ENSP00000473953 ENST00000233609	A0A0B4J2B4 [Direct mapping] 40S ribosomal protein S15; Ribosomal protein S15, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	118 aa 13.7 kDa	No	0
RPS15-007 ENSP00000483399 ENST00000617694		Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		7 aa 0.9 kDa	No	0
RPS15-008 ENSP00000474970 ENST00000591032	S4R417 [Direct mapping] 40S ribosomal protein S15 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	135 aa 15.6 kDa	No	0
RPS15-009 ENSP00000467676 ENST00000586686	K7EM56 [Direct mapping] 40S ribosomal protein S15 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	112 aa 13 kDa	No	0
RPS15-010 ENSP00000466366 ENST00000585665	K7EM56 [Direct mapping] 40S ribosomal protein S15 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	112 aa 13 kDa	No	0
RPS15-011 ENSP00000465055 ENST00000586096	K7EJ78 [Direct mapping] 40S ribosomal protein S15 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003735 [structural constituent of ribosome] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	129 aa 14.8 kDa	No	0
RPS15-012 ENSP00000474433 ENST00000592623	A0A0B4J2B4 [Direct mapping] 40S ribosomal protein S15; Ribosomal protein S15, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	118 aa 13.7 kDa	No	0
RPS15-013 ENSP00000474543 ENST00000591804	K7EM56 [Direct mapping] 40S ribosomal protein S15 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	112 aa 13 kDa	No	0

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