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Several ovarian and prostate cancers along with occasional cases of malignant lymphomas, lung and testicular cancers showed weak to moderate positivity. Remaining malignant cells were generally negative.
Several malignant gliomas, malignant lymphomas, testicular seminomas, colorectal and ovarian cancers showed moderate nuclear staining with additional cytoplasmic positivity in some cells. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
GCA (HGNC Symbol)
Synonyms
GCL
Description
Grancalcin, EF-hand calcium binding protein (HGNC Symbol)
Entrez gene summary
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq, Jul 2008]