Cell atlas - MOGS - The Human Protein Atlas

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MOGS

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	MOGS
Gene description	Mannosyl-oligosaccharide glucosidase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA011322
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011322	MCF7	Endoplasmic reticulum
	HPA011322	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	MOGS (HGNC Symbol)
Synonyms	CWH41, DER7, GCS1
Description	Mannosyl-oligosaccharide glucosidase (HGNC Symbol)
Entrez gene summary	This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	74461057 - 74465410
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115275 (version 83.38)
Entrez gene	7841
UniProt	Q13724 (UniProt - Evidence at protein level)
neXtProt	NX_Q13724
Antibodypedia	MOGS antibodies

PROTEIN BROWSER

MOGS-001	MOGS-002	MOGS-003	MOGS-007	MOGS-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MOGS-001 ENSP00000233616 ENST00000233616	Q13724 [Direct mapping] Mannosyl-oligosaccharide glucosidase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004573 [mannosyl-oligosaccharide glucosidase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006487 [protein N-linked glycosylation] GO:0015926 [glucosidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	837 aa 91.9 kDa	No	1
MOGS-002 ENSP00000410992 ENST00000448666	C9J8D4 [Direct mapping] Mannosyl-oligosaccharide glucosidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	492 aa 54.2 kDa	No	0
MOGS-003 ENSP00000386493 ENST00000409065	B8ZZE2 [Direct mapping] Mannosyl-oligosaccharide glucosidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	209 aa 22.5 kDa	No	1
MOGS-007 ENSP00000396298 ENST00000414701	C9JDQ1 [Direct mapping] Mannosyl-oligosaccharide glucosidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 15.9 kDa	No	0
MOGS-201 ENSP00000388201 ENST00000452063	Q13724 [Direct mapping] Mannosyl-oligosaccharide glucosidase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004573 [mannosyl-oligosaccharide glucosidase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006487 [protein N-linked glycosylation] GO:0015926 [glucosidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	731 aa 80.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.