Cell atlas - GRB14 - The Human Protein Atlas

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GRB14

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GRB14
Gene description	Growth factor receptor-bound protein 14
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (TIME, HUVEC TERT2, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035052
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME, HUVEC TERT2, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035052	A549	Nucleoplasm
	HPA035052	A549	Cytosol
	HPA035052	HEK 293	No staining
	HPA035052	U-2 OS	No staining

GENE INFORMATION
Gene name	GRB14
Synonyms
Description	Growth factor receptor-bound protein 14 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	2
Cytoband	q24.3
Chromosome location (bp)	164492812 - 164621848
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115290 (version 83.38)
Entrez gene	2888
UniProt	Q14449 (UniProt - Evidence at protein level)
neXtProt	NX_Q14449
Antibodypedia	GRB14 antibodies

PROTEIN BROWSER

GRB14-001	GRB14-002	GRB14-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRB14-001 ENSP00000263915 ENST00000263915	Q14449 [Direct mapping] Growth factor receptor-bound protein 14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0009967 [positive regulation of signal transduction] GO:0010008 [endosome membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0050900 [leukocyte migration] Show all	540 aa 61 kDa	No	0
GRB14-002 ENSP00000416786 ENST00000446413	C9JD37 [Direct mapping] Growth factor receptor-bound protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	416 aa 47.6 kDa	No	0
GRB14-005 ENSP00000401702 ENST00000424693	C9JLT6 [Direct mapping] Growth factor receptor-bound protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	155 aa 18.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.