Expression of RTN4 in cancer - Summary - The Human Protein Atlas

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RTN4

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RTN4
Gene description	Reticulon 4
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in the CNS, peripheral nerves and seminiferous duct cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA023977 , CAB005388
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023977	CAB005388

GENE INFORMATION
Gene name	RTN4 (HGNC Symbol)
Synonyms	ASY, KIAA0886, NOGO, NSP-CL
Description	Reticulon 4 (HGNC Symbol)
Entrez gene summary	This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p16.1
Chromosome location (bp)	54972187 - 55112621
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115310 (version 83.38)
Entrez gene	57142
UniProt	Q9NQC3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQC3
Antibodypedia	RTN4 antibodies

PROTEIN BROWSER

RTN4-001	RTN4-002	RTN4-003	RTN4-004	RTN4-006	RTN4-007	RTN4-008	RTN4-009	RTN4-012	RTN4-013	RTN4-014	RTN4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RTN4-001 ENSP00000337838 ENST00000337526	Q9NQC3 [Direct mapping] Reticulon-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007399 [nervous system development] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0021801 [cerebral cortex radial glia guided migration] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030308 [negative regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0042981 [regulation of apoptotic process] GO:0042995 [cell projection] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0051960 [regulation of nervous system development] GO:0060317 [cardiac epithelial to mesenchymal transition] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] GO:0097481 [neuronal postsynaptic density] GO:2000172 [regulation of branching morphogenesis of a nerve] Show all	1192 aa 129.9 kDa	No	2
RTN4-002 ENSP00000322147 ENST00000317610	Q9NQC3 [Direct mapping] Reticulon-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0021801 [cerebral cortex radial glia guided migration] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030308 [negative regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0042981 [regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] GO:2000172 [regulation of branching morphogenesis of a nerve] Show all	373 aa 40.3 kDa	No	2
RTN4-003 ENSP00000384471 ENST00000405240	Q9NQC3 [Direct mapping] Reticulon-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0021801 [cerebral cortex radial glia guided migration] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030308 [negative regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0042981 [regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] GO:2000172 [regulation of branching morphogenesis of a nerve] Show all	986 aa 108.4 kDa	No	2
RTN4-004 ENSP00000411628 ENST00000427710	C9J685 [Direct mapping] Reticulon-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] Show all	91 aa 9.9 kDa	No	0
RTN4-006 ENSP00000385650 ENST00000404909	Q9NQC3 [Direct mapping] Reticulon-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0021801 [cerebral cortex radial glia guided migration] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030308 [negative regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0042981 [regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] GO:2000172 [regulation of branching morphogenesis of a nerve] Show all	986 aa 108.4 kDa	No	2
RTN4-007 ENSP00000350365 ENST00000357732	Q9NQC3 [Direct mapping] Reticulon-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0021801 [cerebral cortex radial glia guided migration] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030308 [negative regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0042981 [regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] GO:2000172 [regulation of branching morphogenesis of a nerve] Show all	392 aa 42.3 kDa	No	2
RTN4-008 ENSP00000378107 ENST00000394609	Q9NQC3 [Direct mapping] Reticulon-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0021801 [cerebral cortex radial glia guided migration] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030308 [negative regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0042981 [regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] GO:2000172 [regulation of branching morphogenesis of a nerve] Show all	199 aa 22.4 kDa	No	2
RTN4-009 ENSP00000489133 ENST00000486085		MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 14.1 kDa	No	0
RTN4-012 ENSP00000397808 ENST00000438462	H7C106 [Direct mapping] Reticulon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] Show all	203 aa 22.7 kDa	No	2
RTN4-013 ENSP00000378109 ENST00000394611	Q9NQC3 [Direct mapping] Reticulon-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0021801 [cerebral cortex radial glia guided migration] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030308 [negative regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0042981 [regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] GO:2000172 [regulation of branching morphogenesis of a nerve] Show all	986 aa 108.4 kDa	No	2
RTN4-014 ENSP00000349944 ENST00000357376	Q9NQC3 [Direct mapping] Reticulon-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0021801 [cerebral cortex radial glia guided migration] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030308 [negative regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0042981 [regulation of apoptotic process] GO:0044822 [poly(A) RNA binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0070062 [extracellular exosome] GO:0071786 [endoplasmic reticulum tubular network organization] GO:2000172 [regulation of branching morphogenesis of a nerve] Show all	986 aa 108.4 kDa	No	2
RTN4-201 ENSP00000384825 ENST00000402434	F8W914 [Direct mapping] Reticulon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0007409 [axonogenesis] GO:0007413 [axonal fasciculation] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] Show all	345 aa 37.1 kDa	No	2

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The Human Protein Atlas

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