Cell atlas - POLE4 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	POLE4
Gene description	Polymerase (DNA-directed), epsilon 4, accessory subunit
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA054979
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA054979	A-431	Nucleus
HPA054979	HeLa	Nucleus
HPA054979	HeLa	Cytosol
HPA054979	U-2 OS	Nucleus
HPA054979	U-2 OS	Cytosol

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000030042 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA054979	NIH 3T3	No staining

GENE INFORMATION
Gene name	POLE4 (HGNC Symbol)
Synonyms	p12
Description	Polymerase (DNA-directed), epsilon 4, accessory subunit (HGNC Symbol)
Entrez gene summary	POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Chromosome	2
Cytoband	p12
Chromosome location (bp)	74958492 - 74970128
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115350 (version 83.38)
Entrez gene	56655
UniProt	Q9NR33 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR33
Antibodypedia	POLE4 antibodies

PROTEIN BROWSER

POLE4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLE4-001 ENSP00000420176 ENST00000483063	Q9NR33 [Direct mapping] DNA polymerase epsilon subunit 4 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex] GO:0008622 [epsilon DNA polymerase complex] GO:0043966 [histone H3 acetylation] GO:0046982 [protein heterodimerization activity] GO:0071897 [DNA biosynthetic process] Show all	117 aa 12.2 kDa	No	0