Expression of ACADL in cancer - Summary

GENERAL INFORMATION
Gene name	ACADL
Gene description	Acyl-CoA dehydrogenase, long chain
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, prostate cancer, renal cancer, thyroid cancer)
HPA (cell line):	Cell line enhanced (HEK93, HeLa, RPTEC TERT1, U-2 OS)
HPA (normal tissue):	Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a mitochondrial pattern in several tissues, most abundant in thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA011990
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, prostate cancer, renal cancer, thyroid cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA011990

GENE INFORMATION
Gene name	ACADL (HGNC Symbol)
Synonyms	ACAD4, LCAD
Description	Acyl-CoA dehydrogenase, long chain (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q34
Chromosome location (bp)	210187939 - 210225491
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115361 (version 83.38)
Entrez gene	33
UniProt	P28330 (UniProt - Evidence at protein level)
neXtProt	NX_P28330
Antibodypedia	ACADL antibodies

PROTEIN BROWSER

ACADL-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACADL-001 ENSP00000233710 ENST00000233710	P28330 [Direct mapping] Long-chain specific acyl-CoA dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0001659 [temperature homeostasis] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0004466 [long-chain-acyl-CoA dehydrogenase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016401 [palmitoyl-CoA oxidase activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0019254 [carnitine metabolic process, CoA-linked] GO:0031966 [mitochondrial membrane] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0042413 [carnitine catabolic process] GO:0042758 [long-chain fatty acid catabolic process] GO:0044242 [cellular lipid catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0046322 [negative regulation of fatty acid oxidation] GO:0050660 [flavin adenine dinucleotide binding] GO:0051289 [protein homotetramerization] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process] GO:0090181 [regulation of cholesterol metabolic process] Show all	430 aa 47.7 kDa	No	0